BAFF Antibody (YA1510)
(Synonyms: TNFSF13B; BAFF; BLYS; TALL1; TNFSF20; ZTNF4; Tumor necrosis factor ligand superfamily member 13B; B lymphocyte stimulator; BLyS; B-cell-activating factor; BAFF; Dendritic cell-derived TNF-like molecule; TNF- and APOL-related leukocyte expressed ligand 1; TALL-1; CD257)BAFF Antibody (YA1510) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to BAFF.
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Host:
Rabbit
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Isotype:
IgG
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Application:
FC, ELISA
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Reactivity :
Human
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Formulation:
Supplied in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide, pH 7.3.
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Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
FC
FC: Flow Cytometry
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ELISA
ELISA: Enzyme Linked Immunosorbent Assay
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|---|---|---|
| Dilution Ratio | 1:50-1:100 | 1:10000 |
Product Details
BAFF Antibody (YA1510) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to BAFF.
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Host Rabbit
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Clonality Recombinant, Monoclonal
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Species ReactivityHuman
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Observed Molecular WeightObserved band size: 31 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
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Calculated Molecular Weight Predicted band size: 31 kDa
Recombinant human BAFF protein
Endogenous
Affinity Chromatography
Non-conjugated
Unmodified
IgG
Product Properties
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Appearance
Liquid
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Formulation
Supplied in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide, pH 7.3.
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
BAFF is a Cytokine that binds to TNFRSF13B/TACI and TNFRSF17/BCMA. TNFSF13/APRIL binds to the same 2 receptors. Together, they form a 2 ligands -2 receptors pathway involved in the stimulation of B- and T-cell function and the regulation of humoral immunity. A third B-cell specific BAFF-receptor (BAFFR/BR3) promotes the survival of mature B-cells and the B-cell response; Isoform 2 seems to inhibit isoform 1 secretion and bioactivity; Acts as a transcription factor for its own parent gene, in association with NF-kappa-B p50 subunit, at least in autoimmune and proliferative B-cell diseases. The presence of Delta4BAFF is essential for soluble BAFF release by IFNG/IFN-gamma-stimulated monocytes and for B-cell survival. It can directly or indirectly regulate the differential expression of a large number of genes involved in the innate immune response and the regulation of apoptosis
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Subcellular Localization
Cell membrane; Single-pass type II membrane protein; Secreted
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Expression
Tissue_specificity:This gene is highly expressed in peripheral blood leukocytes, particularly in monocytes and macrophages. It is also expressed in the spleen, lymph nodes, bone marrow, T cells, and dendritic cells. Expression is lower in the placenta, heart, lungs, fetal liver, thymus, and pancreas. Isomer 2 is expressed in various myeloid cell lines.
Induction:Up-regulated by exposure to IFNG/IFN-gamma. Down-regulated by phorbol myristate acetate/ionomycin treatment -
Isoforms & Post-Translational Modification
Q9Y275 has 3 isomers: Q9Y275-1: 31223 Da (predicted); Q9Y275-2: 29137 Da (predicted); Q9Y275-3: 17578 Da (predicted).
The soluble form derives from the membrane form by proteolytic processing;Isoform 2 is not efficiently shed from the membrane unlike isoform 1;N-glycosylated -
Subunit
Homotrimer. Isoform 2 heteromultimerizes with isoform 1, probably limiting the amount of functional isoform 1 on the cell surface. Isoform 3 is unlikely form trimers or bind to BAFF receptors
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SwissProt ID
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Synonyms
TNFSF13B; BAFF; BLYS; TALL1; TNFSF20; ZTNF4; Tumor necrosis factor ligand superfamily member 13B; B lymphocyte stimulator; BLyS; B-cell-activating factor; BAFF; Dendritic cell-derived TNF-like molecule; TNF- and APOL-related leukocyte expressed ligand 1; TALL-1; CD257
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Research Field
Signal Transduction
Documentation
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