BAFF Antibody (YA1510)

製品番号: HY-P81765: データシート User Guide for Antibodies
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BAFF Antibody (YA1510) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to BAFF.

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容量		在庫状況
50 μL		お問い合わせ
100 μL		お問い合わせ

* アイテムを追加する前、数量をご選択ください

おすすめ:

WB: Western Blot;
IHC-P: Immunohistochemistry-Paraffin;
IHC-F: Immunohistochemistry-Frozen;
ICC/IF: Immunocytochemistry/Immunofluorescence;
IF-Tissue: Immunofluorescence-Tissue;
mIHC: Multiplex Immunohistochemical;
IP: Immunoprecipitation;
ChIP: Chromatin Immunoprecipitation;
FC: Flow Cytometry;
ELISA: Enzyme Linked Immunosorbent Assay

Product Detail
Background
説明

製品説明

BAFF Antibody (YA1510) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to BAFF.

Host

Rabbit

Clonality

Recombinant, Monoclonal

分子量

Predicted band size: 31 kDa;

Observed band size: 31 kDa

Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.

Species Reactivity

Human

SwissProt ID

Q9Y275

Gene ID

10673 [NCBI]

Immunogen

Recombinant human BAFF protein

Application &
Dilution Ratio

Application	Dilution Ratio
FC FC: Flow Cytometry	1:50-1:100
ELISA ELISA: Enzyme Linked Immunosorbent Assay	1:10000

Sensitivity	Endogenous	純度	Affinity Chromatography
Conjugation	Non-conjugated	Modification	Unmodified
Isotype	IgG

Appearance

Liquid

Formulation

Supplied in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide, pH 7.3.

Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

輸送条件

Shipping with blue ice.

Background

Function：Cytokine that binds to TNFRSF13B/TACI and TNFRSF17/BCMA. TNFSF13/APRIL binds to the same 2 receptors. Together, they form a 2 ligands -2 receptors pathway involved in the stimulation of B- and T-cell function and the regulation of humoral immunity. A third B-cell specific BAFF-receptor (BAFFR/BR3) promotes the survival of mature B-cells and the B-cell response; Isoform 2 seems to inhibit isoform 1 secretion and bioactivity; Acts as a transcription factor for its own parent gene, in association with NF-kappa-B p50 subunit, at least in autoimmune and proliferative B-cell diseases. The presence of Delta4BAFF is essential for soluble BAFF release by IFNG/IFN-gamma-stimulated monocytes and for B-cell survival. It can directly or indirectly regulate the differential expression of a large number of genes involved in the innate immune response and the regulation of apoptosis

Subcellular Localization：Cell membrane; Single-pass type II membrane protein; Secreted

Expression：
Tissue_specificity:This gene is highly expressed in peripheral blood leukocytes, particularly in monocytes and macrophages. It is also expressed in the spleen, lymph nodes, bone marrow, T cells, and dendritic cells. Expression is lower in the placenta, heart, lungs, fetal liver, thymus, and pancreas. Isomer 2 is expressed in various myeloid cell lines.

Induction:Up-regulated by exposure to IFNG/IFN-gamma. Down-regulated by phorbol myristate acetate/ionomycin treatment

Isoforms & Post-Translational Modification：Q9Y275 has 3 isomers: Q9Y275-1: 31223 Da (predicted); Q9Y275-2: 29137 Da (predicted); Q9Y275-3: 17578 Da (predicted).
The soluble form derives from the membrane form by proteolytic processing;Isoform 2 is not efficiently shed from the membrane unlike isoform 1;N-glycosylated

Subunit：Homotrimer. Isoform 2 heteromultimerizes with isoform 1, probably limiting the amount of functional isoform 1 on the cell surface. Isoform 3 is unlikely form trimers or bind to BAFF receptors

Database

Entrez Gene: 10673 Human

SwissProt: Q9Y275 Human

OMIM: 603969 Human

Research Field

Signal Transduction

Synonyms

TNFSF13B; BAFF; BLYS; TALL1; TNFSF20; ZTNF4; Tumor necrosis factor ligand superfamily member 13B; B lymphocyte stimulator; BLyS; B-cell-activating factor; BAFF; Dendritic cell-derived TNF-like molecule; TNF- and APOL-related leukocyte expressed ligand 1; TALL-1; CD257

ドキュメンテーション

User Guide for Antibodies (1077 KB)