LRP4 Antibody (YA7100)
(Synonyms: KIAA0816, LRP10, MEGF7, LRP4, Low-density lipoprotein receptor-related protein 4, LRP-4, Multiple epidermal growth factor-like domains 7)LRP4 Antibody (YA7100) is a Mouse-derived and non-conjugated IgG2a monoclonal antibody, targeting to LRP4.
-
Host:
Mouse
-
Isotype:
IgG
-
Application:
FC, ELISA
-
Reactivity :
Human
-
Formulation:
Supplied in PBS with 0.05% sodium azide
-
Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
FC
FC: Flow Cytometry
|
ELISA
ELISA: Enzyme Linked Immunosorbent Assay
|
|---|---|---|
| Dilution Ratio | 1:200-1:400 | 1:10000 |
Product Details
LRP4 Antibody (YA7100) is a Mouse-derived and non-conjugated IgG2a monoclonal antibody, targeting to LRP4.
-
Host Mouse
-
Clonality Monoclonal
-
Species ReactivityHuman
-
Calculated Molecular Weight Predicted band size: 212kDa;
SwissProt: SwissProt: O75096
Purified recombinant fragment of human LRP4 (AA: extra 21-189) expressed in E. Coli.
Endogenous
affinity purified.
Non-conjugated
Unmodified
IgG
Product Properties
-
Appearance
Solution
-
Formulation
Supplied in PBS with 0.05% sodium azide
-
Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
-
Shipping
Shipping with blue ice.
Background
-
Function
The LRP4 protein, a member of the low-density lipoprotein receptor-related protein family, plays a critical role in multiple developmental and physiological processes. It functions as a co-receptor in the Wnt signaling pathway, particularly in the canonical Wnt/β-catenin cascade, where it facilitates the interaction between Wnt ligands and Frizzled receptors, thereby modulating downstream gene expression[1]. LRP4 is essential for neuromuscular junction (NMJ) formation and maintenance, acting as a key regulator in presynaptic differentiation and postsynaptic clustering of acetylcholine receptors[2]. In addition to its role in neural development, LRP4 has been implicated in bone metabolism, where it regulates osteoblast differentiation and mineralization through interactions with sclerostin and other bone-related factors[3]. Recent studies also highlight its involvement in cardiovascular function, including endothelial cell integrity and vascular smooth muscle cell behavior. Furthermore, LRP4 has emerged as a potential therapeutic target in autoimmune diseases such as myasthenia gravis, where autoantibodies against LRP4 disrupt NMJ stability[4]. These findings underscore the multifunctional nature of LRP4 across diverse biological systems.
-
Subcellular Localization
Cell membrane
-
Expression
Tissue_Specificity: Expressed in bone; present in osteoblasts and osteocytes. No expression is observed in osteoclast. Expressed in several regions of the brain -
Isoforms & Post-Translational Modification
O75096: 1905 amino acids, molecular weight 212045 Da.
-
Subunit
Homooligomer
-
SwissProt ID
-
Synonyms
KIAA0816, LRP10, MEGF7, LRP4, Low-density lipoprotein receptor-related protein 4, LRP-4, Multiple epidermal growth factor-like domains 7
Documentation
[1]. Yang LM, et al. FGF20-Expressing, Wnt-Responsive Olfactory Epithelial Progenitors Regulate Underlying Turbinate Growth to Optimize Surface Area. Dev Cell. 2018 Sep 10;46(5):564-580.e5. [Content Brief]
[2]. Cooper KM, et al. Rapid remobilization of magmatic crystals kept in cold storage. Nature. 2014 Feb 27;506(7489):480-3. [Content Brief]
[3]. Ziemlewicz TJ, et al. Opportunistic Quantitative CT Bone Mineral Density Measurement at the Proximal Femur Using Routine Contrast-Enhanced Scans: Direct Comparison With DXA in 355 Adults. J Bone Miner Res. 2016 Oct;31(10):1835-1840. [Content Brief]
[4]. Wang XW, et al. [Clinical significance of hyponatremia in hip fracture in elderly patients]. Zhonghua Yi Xue Za Zhi. 2021 Feb 23;101(7):487-491. Chinese. [Content Brief]
Powered by Bioz
