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MTMR2 Antibody (YA8054)

(Synonyms: CMT4B; CMT4B1)

MTMR2 Antibody (YA8054) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to MTMR2.

For research use only. We do not sell to patients.
  • Host:

    Mouse

  • Isotype:

    IgG1

  • Application:

    FC

  • Reactivity :

    Human, Mouse, Rat

  • Formulation:

    Spplied in PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.

  • Conjugation:
    Non-conjugated
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To place orders, for customer services and technical support, please contact: MedChemExpress USA

Tel: 609-228-6898 E-mail: [email protected] [email protected]

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Applications

Application
FC Info
FC: Flow Cytometry
Dilution Ratio 1:100

Product Details

Description

MTMR2 Antibody (YA8054) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to MTMR2.

  • Host Mouse
  • Clonality Monoclonal
  • Species Reactivity
    Human, Mouse, Rat
  • Calculated Molecular Weight Predicted band size: 73.2 kDa
Immunogen

Full length human recombinant protein of human MTMR2 produced in HEK293T cell.

Sensitivity

Endogenous

Purification

Affinity purified

Conjugation

Non-conjugated

Modification

Unmodified

Isotype

IgG1

Product Properties

  • Appearance

    Liquid

  • Formulation

    Spplied in PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.

  • Storage & Stability

    Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

  • Shipping

    Shipping with blue ice.

Background

  • Function

    MTMR2 is a Lipid phosphatase that specifically dephosphorylates the D-3 position of phosphatidylinositol 3-phosphate and phosphatidylinositol 3,5-bisphosphate, generating phosphatidylinositol and phosphatidylinositol 5-phosphate. Regulates the level of these phosphoinositides critical for various biological processes including autophagy initiation and autophagosome maturation[1][2][3][4][5].

  • Subcellular Localization

    Cytoplasm,Early endosome membrane,Cytoplasm, perinuclear region,Cell projection, axon,Endosome membrane

  • Isoforms & Post-Translational Modification

    Q13614 has two isomers: Q13614-1: 73381 Da (predicted); Q13614-2: 65959 Da (predicted).
    Phosphorylation at Ser-58 decreases MTMR2 localization to endocytic vesicular structures

  • Subunit

    Homodimer (via coiled-coil domain) (PubMed:12668758, PubMed:15998640)

  • SwissProt ID

    Q13614

  • Synonyms

    CMT4B; CMT4B1

MTMR2 Antibody (YA8054) Related Classifications

MOQ
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100 mg

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Measured by its ability to inhibit anti-CD3-induced proliferation of stimulated CTLL-2 mouse cytotoxic T cells. The ED50 this effect is 0.8023 μg/ml, corresponding to a specific activity is 1246.42 units/mg.

Assay Types
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