PDGFD Antibody (YA7882)
(Synonyms: IEGF; MSTP036; SCDGF-B; SCDGFB)PDGFD Antibody (YA7882) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to PDGFD.
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Host:
Mouse
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Isotype:
IgG1
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Application:
FC
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Reactivity :
Human, Mouse, Rat
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Formulation:
Spplied in PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
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Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
FC
FC: Flow Cytometry
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|---|---|
| Dilution Ratio | 1:100 |
Product Details
PDGFD Antibody (YA7882) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to PDGFD.
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Host Mouse
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Clonality Monoclonal
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Species ReactivityHuman, Mouse, Rat
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Calculated Molecular Weight Predicted band size: 40.2 kDa
Human recombinant protein fragment corresponding to amino acids 19-247 of human PDGFD produced in E.coli.
Endogenous
Affinity purified
Non-conjugated
Unmodified
IgG1
Product Properties
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Appearance
Solution
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Formulation
Spplied in PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
PDGFD is a Growth factor that plays an essential role in the regulation of embryonic development, cell proliferation, cell migration, survival and chemotaxis. Potent mitogen for cells of mesenchymal origin. Plays an important role in wound healing. Induces macrophage recruitment, increased interstitial pressure, and blood vessel maturation during angiogenesis. Can initiate events that lead to a mesangial proliferative glomerulonephritis, including influx of monocytes and macrophages and production of extracellular matrix
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Subcellular Localization
Secreted
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Expression
Tissue_Specificity: Expressed at high levels in the heart, pancreas, adrenal gland and ovary and at low levels in placenta, liver, kidney, prostate, testis, small intestine, spleen and colon. In the kidney, expressed by the visceral epithelial cells of the glomeruli. A widespread expression is also seen in the medial smooth muscle cells of arteries and arterioles, as well as in smooth muscle cells of vasa rectae in the medullary area. Expressed in the adventitial connective tissue surrounding the suprarenal artery. In chronic obstructive nephropathy, a persistent expression is seen in glomerular visceral epithelial cells and vascular smooth muscle cells, as well as de novo expression by periglomerular interstitial cells and by some neointimal cells of atherosclerotic vessels. Expression in normal prostate is seen preferentially in the mesenchyme of the gland while expression is increased and more profuse in prostate carcinoma. Expressed in many ovarian, lung, renal and brain cancer-derived cell lines -
Isoforms & Post-Translational Modification
Q9GZP0 has two isomers: Q9GZP0-1: 42848 Da (predicted); Q9GZP0-2: 42167 Da (predicted).
Activated by proteolytic cleavage -
Subunit
Homodimer; disulfide-linked
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SwissProt ID
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Synonyms
IEGF; MSTP036; SCDGF-B; SCDGFB
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