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Cat. No.: HY-P88661

RAMP2 Antibody (YA8345)

RAMP2 Antibody (YA8345) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to RAMP2.

For research use only. We do not sell to patients.

Formulation:
Spplied in PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Applications

Application	IHC-P IHC-P: Immunohistochemistry-Paraffin	FC FC: Flow Cytometry
Dilution Ratio	1:150-500	1:100

Description

RAMP2 Antibody (YA8345) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to RAMP2.

Immunogen

Full length human recombinat protein of human RAMP2 produced in HEK293T cell.

Sensitivity

Endogenous

Purification

Affinity purified

Conjugation

Non-conjugated

Modification

Unmodified

Isotype

IgG1

Appearance

Liquid
Formulation

Spplied in PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
Shipping

Shipping with blue ice.

Function

RAMP2 is an Accessory protein that interacts with and modulates the function of G-protein coupled receptors including calcitonin gene-related peptide type 1 receptor (CALCRL) and calcitonin receptor (CALCR). Required for the transport of CALCRL to the plasma membrane. Together with CALCRL, form a receptor complex for adrenomedullin/ADM. Together with CALCR, act as a receptor complex for calcitonin/CT/CALC. Together with CALCR, also act as a receptor complex for amylin/IAPP^[1]^[2]^[3]^[4].
Subcellular Localization

Cell membrane
Expression

Tissue_Specificity: Strongly expressed in lung, breast, immune system and fetal tissues
Isoforms & Post-Translational Modification

O60895 has two isomers: O60895-1: 19608 Da (predicted); O60895-2: 20063 Da (predicted).
Subunit

Heterodimer of CALCRL and RAMP2; the interaction forms the receptor complex for adrenomedullin/ADM (PubMed:30115739)
SwissProt ID

O60895