TIMD4 Antibody (YA4427)
(Synonyms: TIM4; SMUCKLER)TIMD4 Antibody (YA4427) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to TIMD4.
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Host:
Mouse
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Isotype:
IgG
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Application:
ICC/IF, FC, ELISA
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Reactivity :
Human
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Formulation:
Supplied in PBS with 0.05% sodium azide
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Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
ICC/IF
ICC/IF: Immunocytochemistry/
Immunofluorescence |
FC
FC: Flow Cytometry
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ELISA
ELISA: Enzyme Linked Immunosorbent Assay
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|---|---|---|---|
| Dilution Ratio | 1:50-1:200 | 1:200-1:400 | 1:10000 |
Product Details
TIMD4 Antibody (YA4427) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to TIMD4.
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Host Mouse
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Clonality Monoclonal
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Species ReactivityHuman
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Observed Molecular WeightObserved band size: 70 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
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Calculated Molecular Weight Predicted band size: 42 kDa
Purified recombinant fragment of human TIMD4 (AA: extra 25-314) expressed in E. Coli.
affinity purified.
Non-conjugated
Unmodified
IgG
Product Properties
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Appearance
Solution
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Formulation
Supplied in PBS with 0.05% sodium azide
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
TIMD4 is a Phosphatidylserine receptor that plays different role in immune response including phagocytosis of apoptotic cells and T-cell regulation. Controls T-cell activation in a bimodal fashion, decreasing the activation of naive T-cells by inducing cell cycle arrest, while increasing proliferation of activated T-cells by activating AKT1 and ERK1/2 phosphorylations and subsequent signaling pathways. Also plays a role in efferocytosis which is the process by which apoptotic cells are removed by phagocytic cells. Mechanistically, promotes the engulfment of apoptotic cells or exogenous particles by securing them to phagocytes through direct binding to phosphatidylserine present on apoptotic cells, while other engulfment receptors such as MERTK efficiently recognize apoptotic cells and mediate their ingestion. Additionally, promotes autophagy process by suppressing NLRP3 inflammasome activity via activation of LKB1/PRKAA1 pathway in a phosphatidylserine-dependent mechanism; (Microbial infection) Plays a positive role in exosome-mediated trafficking of HIV-1 virus and its entry into immune cells[1][2][3].
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Subcellular Localization
Cell membrane; Single-pass type I membrane protein; Secreted, extracellular exosome
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Isoforms & Post-Translational Modification
Q96H15 has 2 isomers: Q96H15-1: 41578 Da (predicted); Q96H15-2: 38536 Da (predicted).
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Subunit
Interacts with MERTK; this interaction enhances TIMD4-mediated efferocytosis (PubMed:32640697). Interacts with EPHA2 (PubMed:34067457)
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SwissProt ID
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Synonyms
TIM4; SMUCKLER
Documentation
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