TIMD4 - T cell immunoglobulin and mucin domain containing 4 Gene

Homo sapiens

Also known as TIM4; SMUCKLER

Gene ID: 91937 | Gene type: protein coding

About TIMD4

Cytogenetic location: 5q33.3 Genomic coordinates (GRCh38): 5:156,919,292-156,963,226 (from NCBI)

This gene has 3 transcripts (splice variants), 162 orthologues and 3 paralogues. Biased expression in lymph node (RPKM 8.4), testis (RPKM 2.6) and 5 other tissues.

Summary

Predicted to enable phosphatidylserine binding activity. Predicted to act upstream of or within apoptotic cell clearance. Predicted to be integral component of membrane. [provided by Alliance of Genome Resources, Apr 2022]

TIMD4 Products(2)

mRNA	Protein	Name
NM_001146726.2	NP_001140198.1	T-cell immunoglobulin and mucin domain-containing protein 4 isoform 2 precursor
NM_138379.3	NP_612388.2	T-cell immunoglobulin and mucin domain-containing protein 4 isoform 1 precursor

TIMD4 Protein Structure

V-set

0
100
200
300
378 a.a.

Protein Preferred Names

Protein Names

T-cell immunoglobulin and mucin domain-containing protein 4

T-cell immunoglobulin mucin receptor 4

Recombinant TIMD4 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P70976	TIM-4/TIMD-4 Protein, Human (HEK293, His)	AAH08988.1 (E25-L315)	≥95%
HY-P75552	TIM-4/TIMD-4 Protein, Human (Biotinylated, HEK293, His)	Q96H15 (M1-L315)	≥95%

Related Diseases

Diseases

Alias

Histiocytic Sarcoma

Malignant Histiocytosis

Langerhans Cell Sarcoma

Malignant Langerhans Cell Sarcoma

Malaria

Malaria, Susceptibility To	Malaria, Resistance To
Malaria, Cerebral	Cerebral Malaria
Malaria, Severe, Susceptibility To	Malaria, Severe, Resistance To
Malaria, Cerebral, Susceptibility To	Induced Malaria
Malaria, Vivax, Protection Against	Malaria, Severe
Malaria, Cerebral, Reduced Risk Of	Malaria, Protection Against
Resistance To Malaria Due To G6pd Deficiency	Malaria Due To G6pd Deficiency
Malarial Encephalitis	CM
Malaria Cerebral	Susceptibility To Malaria
Acute Pernicious Fever	Aestivo-Autumnal Fever
Aestivo Autumnal Malaria	Chagres Fever
Continued Malaria Fever	Estivo-Autumnal Fever
Estivo-Autumnal Malaria	Estivo-Autumnal Malarial Fever
Falciparum Fever	Malignant Tertian Fever
Malignant Tertian Malaria	Pernicious Intermittent Fever
Pernicious Malaria	Quotidian Malaria
Subtertian Fever	Subtertian Malaria Fever
Subtertian Malignant Tertian Malaria	Tropical Malaria
Algid Malaria	Bilious Haemoglobinuric Fever
Black Water Fever	Blackwater Fever
Malarial Blackwater Fever	Severe Malarial Falciparum
West African Fever	Malarial Haematinuria
Haemoglobinuric Fever	Haemoglobinuric Malaria
Severe Plasmodium Falciparum Malaria	Malarial Haemoglobinuria
Malarial Haematuria	Falciparum Malaria [Malignant Tertian]
Malaria Tropica	Malarial Shock
Chagres Virus Disease	Malignant Malaria
Mtm - [Malignant Tertian Malaria]	Tm -[Malignant Tertian Malaria]
Panama Fever	St - [Subtertian Malaria]
Malarial Quotidian	Benign Tertian Malaria
Tertian Ague	Vivax Fever
Plasmodium Vivax Malaria Nos	Btm - [Benign Tertian Malaria]
Bt - [Benign Tertian Malaria]	Vivax Malaria
Benign Tertian Vivax Malaria	Tertian Malaria
Quartan Malaria	Quartan Ague
Quartan Fever	Plasmodium Malariae Malaria Nos
Quartan Malarial	Malaria By Plasmodium Malariae
Malariae Malaria	Ovale Tertian Malaria
Plasmodium Ovale Fever	Malaria Fever By Plasmodium Ovale
Ovale Malaria	Malaria By Plasmodium Ovale
Malarial Ovale	Marsh Fever
Remittent Congestive Fever	Coastal Fever
Remittent Gastric Fever	Miasmatic Fever
Congestive Remittent Fever	Intermittent Fever
Jungle Fever	Paludism
Cameroon Fever	Ague
Corsican Fever	Intermittent Bilious Fever
Disease Due To Plasmodiidae	Malarial Fever
Plasmodiosis	Remittent Fever
Roman Fever	Malaria Fever Nos
Malaria Nos	Paludal Fever
Clinically Diagnosed Malaria	Clinically Diagnosed Malaria Without Parasitological Confirmation
Congestive Fever	Malarial Cachexia
Marsh Cachexia	Paludal Cachexia
Recurrent Malaria	Remittent Malaria

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS14525	TIMD4 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	TIMD4	VGNC	VGNC:102345
Bos taurus	TIMD4	VGNC	VGNC:55313
Rattus norvegicus	TIMD4	RGD	RGD:1564516
Mus musculus	TIMD4	MGD	MGI:2445125
Macaca mulatta	TIMD4	VGNC	VGNC:79477
Canis familiaris	TIMD4	VGNC	VGNC:51911
Macaca fascicularis	TIMD4	NCBI
Others	TIMD4	NCBI

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