AP 811 acetate

Cat. No.: HY-P1419A: FAQs
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AP 811 acetate is a selective atrial natriuretic peptide clearance receptor (ANP-CR, NPR3) antagonist with a K_i of 0.48 nM. AP 811 acetate displays >20000-fold selectivity for NPR3 over NPR1. AP 811 acetate abolishes ANP-induced pump stimulation.

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AP 811 acetate Chemical Structure

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AP 811

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Description	AP 811 acetate is a selective atrial natriuretic peptide clearance receptor (ANP-CR, NPR3) antagonist with a K_i of 0.48 nM. AP 811 acetate displays >20000-fold selectivity for NPR3 over NPR1. AP 811 acetate abolishes ANP-induced pump stimulation^[1]^[2].
IC₅₀ & Target	Ki: 0.48 nM (NPR3)^[1]
In Vitro	In proliferating cardiomyocytes, AP 811 acetate (10-500 nM) could completely abolish the enhanced cardiomyocyte proliferation seen with low concentration ANP (10 nM)^[3]. MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. AP 811 acetate Related Antibodies
Formula	C₄₆H₆₆N₁₂O₈.xC₂H₄O₂
Shipping	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation	Data Sheet (268 KB) Handling Instructions (2659 KB)
References	[1]. Veale CA, et al. The discovery of non-basic atrial natriuretic peptide clearance receptor antagonists. Part 1. Bioorg Med Chem Lett. 2000;10(17):1949-1952. [Content Brief] [2]. William M, et al. Natriuretic peptides stimulate the cardiac sodium pump via NPR-C-coupled NOS activation. Am J Physiol Cell Physiol. 2008;294(4):C1067-C1073. [Content Brief] [3]. Jason R Becker, et al. Differential activation of natriuretic peptide receptors modulates cardiomyocyte proliferation during development. Development. 2014 Jan;141(2):335-45. [Content Brief]

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This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

AP 811AP811AP-811OtherspumpstimulationatrialnatriureticpeptidecardiovasculardiseasesInhibitorinhibitorinhibit

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AP 811 acetate

Other Forms of AP 811 acetate:

AP 811 acetate Related Antibodies

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