Apoptosis inducer 62
Apoptosis inducer 62 is an apoptosis inducer that reduces the expression levels of anti-apoptotic proteins Bcl-2 and Bcl-xL. Apoptosis inducer 62 induces ROS accumulation, mitochondrial membrane potential depolarization, DNA damage, cell cycle arrest. Apoptosis inducer 62 exhibits activity in colorectal tumor xenograft models. Apoptosis inducer 62 can be used for research related to colorectal cancer.
For research use only. We do not sell to patients.
- Formula: C36H42F3NO3
- Molecular Weight:593.72
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
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Biological Activity
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Bcl-xL |
Bcl-2 |
Apoptosis inducer 62 (Compound 28a) (1 μM; 72 h) potently inhibits the proliferation of HCT116, MIA-PaCa-2, HepG-2 and HeLa cancer cells, with IC50 values of 0.34, 0.6, 0.71 and 0.77 μM[1].
Apoptosis inducer 62 (0.5-2 μM; 48 h) significantly increases intracellular ROS levels in HCT116 cells in a concentration-dependent manner in vitro[1].
Apoptosis inducer 62 (0.5-2 μM; 48 h) induces mitochondrial membrane potential depolarization in HCT116 cells in a concentration-dependent manner in vitro[1].
Apoptosis inducer 62 (0.5-2 μM; 48 h) significantly induces apoptosis in HCT116 cells in a concentration-dependent manner in vitro[1].
Apoptosis inducer 62 (0.5-2 μM; 48 h) induces S-phase cell cycle arrest in HCT116 cells in a concentration-dependent manner in vitro[1].
Apoptosis inducer 62 (0.25-1 μM; 24 h) regulates the expression of apoptosis-related proteins and DNA damage-related proteins (Bcl-xL, Bcl-2, Cyt c, γ-H2AX) in HCT116 cells, and promotes cell apoptosis and DNA damage[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:HCT116 cells
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Concentration:0.5, 1 and 2 μM
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Incubation Time:48 h
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Result:Significantly induced apoptosis in HCT116 cells in a concentration-dependent manner.
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Cell Line:HCT116 cells
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Concentration:0.5, 1 and 2 μM
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Incubation Time:48 h
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Result:Significantly induced S-phase cell cycle arrest in HCT116 cells in a concentration-dependent manner.
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Cell Line:HCT116 cells
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Concentration:0.25, 0.5 and 1 μM
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Incubation Time:24 h
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Result:Decreased Bcl-xL and Bcl-2.
Increased Cyt c and γ-H2AX.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:BALB/c nude (female, 5 weeks old)[1]
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Dosage:2 mg/kg
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Administration:i.p.; daily; 14 days
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Result:Achieved a tumor growth inhibition rate (TGI) of 47.9%.
Significantly suppressed tumor volume and tumor weight compared to the control group.
Caused no obvious body weight loss during the 14-day treatment period.
Chemical Information
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Molecular Weight 593.72
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Formula C36H42F3NO3
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SMILES
O=C1C=C2[C@]3(C)CC[C@@]4(C)[C@]5([H])C[C@@](C(N)=O)(CC6=CC=C(C(F)(F)F)C=C6)CC[C@]5(C)CC[C@]4(C)C3=CC=C2C(C)=C1O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Apoptosis inducer 62 Related Classifications
HY-184302 Related Classifications
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- Apoptosis inducer 62
- Apoptosis inducer62
- Apoptosis inducer-62
- Apoptosis
- Bcl-2 Family
- Reactive Oxygen Species (ROS)
- DNA/RNA Synthesis
- colorectal tumor xenograft model
- Bcl-2
- mitochondrial membrane potential depolarization
- γ-H2AX
- Bcl-xL
- reactive oxygen species
- apoptosis
- colorectal cancer cells
- cell cycle arrest
- HCT116
- Inhibitor
- inhibitor
- inhibit