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Alagebrium bromide

(Synonyms: ALT711 bromide)
6 Cited Publications
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Based on 6 publication(s) in Google Scholar

Alagebrium bromide is an analog of Alagebrium Chloride (HY-106024B), a glucose cross-link blocker. Alagebrium Chloride disrupts glucose cross-links and may improve ventricular and arterial compliance. Alagebrium Chloride improves left ventricular diastolic filling and has the potential to inhibit diastolic heart failure (DHF).

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  • CAS. Nr.: 181069-80-7
  • Formel: C13H14BrNOS
  • Molecular Weight:312.23
  • Speicherung:

    Please store the product under the recommended conditions in the Certificate of Analysis.

  • Alagebrium bromide Chemical Structure
    Alagebrium bromide Chemical Structure
  • Experimental Validation Results for Alagebrium bromide
  • Experimental Validation Results for Alagebrium bromide
  • Experimental Validation Results for Alagebrium bromide
  • Experimental Validation Results for Alagebrium bromide
  • Experimental Validation Results for Alagebrium bromide
  • Experimental Validation Results for Alagebrium bromide
  • Experimental Validation Results for Alagebrium bromide
CAS. Nr.: 181069-80-7
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  • Cell Migration/Invasion Assay
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  • Alagebrium bromide Chemical Structure
    Alagebrium bromide Chemical Structure
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    Alagebrium bromide purchased from MedChemExpress. Usage Cited in: Biomaterials. 2026 Jan:324:123504. [Abstract]

    Customer Validation
     Alagebrium chloride (ALT-711; ALT; 100 μM; 3 days) suppressed RAGE expression in both neurons and bECs in the aged NV model with Aβ treatment.

  • 1/16

    Alagebrium bromide purchased from MedChemExpress. Usage Cited in: Biomaterials. 2026 Jan:324:123504. [Abstract]

    Customer Validation
     Alagebrium chloride (ALT-711; ALT; 100 μM; 3 days) recovered neuronal cell viability under aged conditions.

  • 1/16

    Alagebrium bromide purchased from MedChemExpress. Usage Cited in: Mol Med. 2025 Jan 18;31(1):15. [Abstract]

    Customer Validation
     Alagebrium chloride (ALT711; 10 μM; ahead 2 h; 24-48 h) decreased the protein expression of p-AMPK, Nrf2, and HO-1, could eliminate the differences between D-mannose treated or untreated high-glucose-induced NHEK in NHEK cells.

  • 1/16

    Alagebrium bromide purchased from MedChemExpress. Usage Cited in: Mol Med. 2025 Jan 18;31(1):15. [Abstract]

    Customer Validation
     Alagebrium chloride (ALT711; 10 μM; 48 h) recovered high-glucose and D-mannose-induced cell migration in NHEK cells.

  • 1/16

    Alagebrium bromide purchased from MedChemExpress. Usage Cited in: Mol Med. 2025 Jan 18;31(1):15. [Abstract]

    Customer Validation
     Alagebrium chloride (ALT711; 10 μM) recovered high-glucose and D-mannose-inhibited mRNA expression of involucrin, Loricrin, and filaggrin in NHEK cells.

  • 1/16

    Alagebrium bromide purchased from MedChemExpress. Usage Cited in: Mol Med. 2025 Jan 18;31(1):15. [Abstract]

    Customer Validation
     Alagebrium chloride (ALT711; 10 μM) decreased high-glucose and D-mannose-induced mRNA expression of TNF-α and IL-8 in NHEK cells.

  • 1/16

    Alagebrium bromide purchased from MedChemExpress. Usage Cited in: Am J Transl Res. 2019 Mar 15;11(3):1569-1580. [Abstract]

    Customer Validation
     Western blotting analysis of TSP-1 protein expression, and results show that TSP-1 expression in HUVECs treated with ALT-711 under CML-BSA condition is enhanced by miR-27b inhibitor.

  • Alagebrium bromide