BET-IN-26
BET-IN-26 (compound 13a) is a potent, selective and orally active BD1 inhibitor with IC50 values of 0.0055, 9.0 µM for BD1, BD2, respectively. BET-IN-26 decreases LPS (HY-D1056) induced serum levels of IL-6 and MCP-1.
Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.
- Formel: C26H36N6O2S
- Molecular Weight:496.67
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biologische Aktivität
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Chemical Information
- Reinheit & Dokumentation
- Verweise
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Help & FAQs
Biologische Aktivität
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BD1 0.0055 μM (IC50) |
BD2 9.0 μM (IC50) |
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Cell Line
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Type | Value | Description | References |
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| Monocyte | IC50 |
0.001 μM
Compound: 13a
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Inhibition of LPS-induced MCP-1 production in mouse Monocyte
Inhibition of LPS-induced MCP-1 production in mouse Monocyte
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[PMID: 38876177] |
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Seven-week-old male BALB/cAnNCrlCrlj mice[1]
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Dosage:10, 100 mg/kg
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Administration:P.o.
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Result:Effectively suppresses LPS (20 µg/head, ip) induced serum levels of IL-6 and MCP-1.
Chemical Information
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Molecular Weight 496.67
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Formel C26H36N6O2S
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SMILES
O=C1C2=CN(CC3CC(C(NC4CCCCC4)=O)CCN(C)C3)N=C2C(C5=NC(C)=CS5)=CN1C
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
BET-IN-26 Related Classifications
HY-162622 Related Classifications
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