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Art. -Nr.: HY-122108

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Ilicicolin A

(Synonyms: LL-Z 1272-alpha)

Ilicicolin A is a potent anticancer agent. Ilicicolin A induces apoptosis. Ilicicolin A inhibits cell growth and colony formation. Ilicicolin A shows antitumor activity. Ilicicolin A has the potential for the research of prostate cancer.

Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.

CAS. Nr.: 22581-06-2
Formel: C₂₃H₃₁ClO₃
Molecular Weight:390.94

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (267 KB)

Ilicicolin A Chemical Structure

CAS. Nr.: 22581-06-2

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- In Vitro
- In Vivo
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

In Vitro

Ilicicolin A (0, 2.5, 5, 10 µM; 48 h) induces apoptosis in 22Rv1, C4-2B cells^[1].
Ilicicolin A (0, 2.5, 5, 10 µM) inhibits cell growth and colony formation in 22Rv1 cells and C4-2B cells in a dose-dependent manner^[1].
Ilicicolin A (0, 2.5, 5, 10 µM; 48 h) decreases the protein expression of EZH2, AURKA, PLK1, FoxM1, Cyclin B2, AR, c-Myc, cyclin D1^[1].
Ilicicolin A (0, 2.5, 5, 10 µM; 48 h) decreases the mRNA expression of AR, ALK2, ALK3 in a dose-dependent manner^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[1]

Cell Line:

22Rv1, C4-2B cells
Concentration:

0, 2.5, 5, 10 µM
Incubation Time:

96 h
Result:

Inhibited cell growth in a dose-dependent manner.

Apoptosis Analysis^[1]

Cell Line:

22Rv1, C4-2B cells
Concentration:

0, 2.5, 5, 10 µM
Incubation Time:

48 h
Result:

Induced apoptosis and increased the expression of cleaved-PARP1 and cleaved caspase 7.

Western Blot Analysis^[1]

Cell Line:

22Rv1, C4-2B cells
Concentration:

0, 2.5, 5, 10 µM
Incubation Time:

48 h
Result:

Decreased the expression of EZH2, AURKA, PLK1, FoxM1, Cyclin B2, AR, c-Myc, cyclin D1.

RT-PCR^[1]

Cell Line:

22Rv1, C4-2B cells
Concentration:

0, 2.5, 5, 10 µM
Incubation Time:

48 h
Result:

Decreased the mRNA expression of AR, ALK2, ALK3 in a dose-dependent manner.

In Vivo

Ilicicolin A (10 mg/kg; i.p.; six times a week for 3 weeks) inhibits tumor growth in mice^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Four-week-old, 18 g, male NOD/SCID mice (22Rv1 cells) ^[1]
Dosage:

10 mg/kg
Administration:

I.p.; six times a week for 3 weeks
Result:

Suppressed tumor growth but did not elicit a significant effect on bodyweight.

Chemical Information

CAS. Nr. 22581-06-2
Molecular Weight 390.94
Formel C₂₃H₃₁ClO₃
SMILES

O=CC1=C(C(C/C=C(CC/C=C(CC/C=C(C)\C)\C)\C)=C(C(Cl)=C1C)O)O
Synonyms

LL-Z 1272-alpha
Structure Classification
- Phenols
- Polyphenols
Initial Source
- Microorganisms
Fusarium sp.
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (267 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Guo L, et al. Ilicicolin A Exerts Antitumor Effect in Castration-Resistant Prostate Cancer Via Suppressing EZH2 Signaling Pathway. Front Pharmacol. 2021 Oct 27;12:723729. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

MOQ

Minimum order quantity

100 mg

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