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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
23 Results for "
VWF
" in MedChemExpress (MCE) Product Catalog:
Products (23)
23 Results for "VWF" in MCE Product Catalog:
1
Target:
Forschungsgebiete:
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1 Cited Publications
Art. -Nr.: HY-P5354
Target:
Forschungsgebiete:
1
1 Cited Publications
Art. -Nr.: HY-P5354A
Target:
Forschungsgebiete:
Art. -Nr.: HY-153999A
Reinheit: 98.20%
Synonyms: BT200 sodium
Forschungsgebiete:
Rondaptivon pegol (BT200) sodium is an aptamer targeting von Willebrand factor (VWF), with an EC50 of 33 nM in humans. Rondaptivon pegol sodium effectively alleviates acute myocardial ischemia-reperfusion injury in mice by inhibiting VWF activity, reducing microvascular obstruction, inflammatory responses and cardiomyocyte apoptosis (apoptosis). Rondaptivon pegol sodium inhibits the binding of VWF to platelet glycoprotein GPIb, thereby preventing arterial thrombosis in cynomolgus monkeys. Rondaptivon pegol sodium can be used in research related to arterial thrombosis, stroke, myocardial infarction and myocardial ischemia-reperfusion injury .
Art. -Nr.: HY-138053
CAS. Nr.: 90831-71-3
Synonyms: Ristomycin III
Target:
Forschungsgebiete:
Ristocetin A monosulfate (Ristomycin III) is a glycopeptide antibiotic that binds to von Willebrand factor (VWF) and bacterial cell wall components. Ristocetin A (monosulfate) interferes with the biosynthesis of bacterial peptidoglycan by inhibiting transpeptidation. As an inducer of platelet adhesion and aggregation, Ristocetin A (monosulfate) drives conformational changes by binding to the A1 domain of VWF, thereby activating downstream signaling pathways and promoting cytoskeletal rearrangement. Ristocetin A (monosulfate) not only enhances platelet adhesion and spreading on immobilized VWF, but also induces the formation of asymmetric dimers with anticooperativity between platelets and plasma VWF. Ristocetin A (monosulfate) is widely used in studies related to thromboembolic diseases and bacterial infections .
Synonyms: BT200
Forschungsgebiete:
Rondaptivon pegol (BT200) is an aptamer targeting von Willebrand factor (VWF), with an EC50 of 33 nM in humans. Rondaptivon pegol effectively alleviates acute myocardial ischemia-reperfusion injury in mice by inhibiting VWF activity, reducing microvascular obstruction, inflammatory responses and cardiomyocyte apoptosis (apoptosis). Rondaptivon pegol inhibits the binding of VWF to platelet glycoprotein GPIb, thereby preventing arterial thrombosis in cynomolgus monkeys. Rondaptivon pegol can be used in research related to arterial thrombosis, stroke, myocardial infarction and myocardial ischemia-reperfusion injury .
Art. -Nr.: HY-P99875
CAS. Nr.: 2252477-42-0
Synonyms: BIVV-001; Altuvoct
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Art. -Nr.: HY-DP5354AF
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Art. -Nr.: HY-147079A
Reinheit: 92.75%
Synonyms: ARC 1779 sodium
Target:
Forschungsgebiete:
Egaptivon pegol sodium is an aptamer, which blocks binding of the von Willebrand Factor (VWF) to platelet GPIb receptors. Egaptivon pegol sodium has anti-thrombotic efficacy.
Art. -Nr.: HY-147079
CAS. Nr.: 934868-74-3
Synonyms: ARC 1779
Target:
Forschungsgebiete:
Egaptivon pegol (ARC1779) is an aptamer, which blocks binding of the von Willebrand Factor (VWF) to platelet GPIb receptors. Egaptivon pegol has anti-thrombotic efficacy.
0 Images
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Art. -Nr.: HY-156501
Art. -Nr.: HY-P990544
Synonyms: AJW 200; AJvW 2
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Art. -Nr.: HY-138019
CAS. Nr.: 2088247-61-2
Target:
Forschungsgebiete:
SP-8008 is a selective shear stress-induced platelet aggregation (SIPA) inhibitor with an IC50 of 1.44 μM. SP-8008 effectively interferes von Willebrand factor (vWF) and platelet glycoprotein (GP) Ib interaction. SP-8008 exerts its antithrombotic effect by selectively inhibiting shear stress-induced platelet aggregation .
Art. -Nr.: HY-RS15735
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VWF Human Pre-designed siRNA Set A contains three designed siRNAs for VWF gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Art. -Nr.: HY-RS17403
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Forschungsgebiete:
Vwf Mouse Pre-designed siRNA Set A contains three designed siRNAs for Vwf gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
Art. -Nr.: HY-RS23858
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Forschungsgebiete:
Vwf Rat Pre-designed siRNA Set A contains three designed siRNAs for Vwf gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
Art. -Nr.: HY-153998
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BT100 (sodium), a aptamer, inhibits binding of von Willebrand factor (VWF) to platelet glycoprotein GPIb, preventing arterial thrombosis .
Art. -Nr.: HY-P82661A
Synonyms: VWF; von Willebrand factor; von Willebrand antigen II; F8VWF
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
