Cat. No.: HY-N2526

Nervonic acid

(Synonyms: Selacholeic acid; cis-15-Tetracosenoic acid)

5 Cited Publications

Customer Review

Based on 5 publication(s) in Google Scholar

Nervonic acid is a monounsaturated fatty acid with oral activity. Nervonic acid exerts anti-inflammatory activity by inhibiting NF-κB signaling. Nervonic acid can be used in the study of neurodegenerative diseases.

For research use only. We do not sell to patients.

Purity: 99.89%
CAS No.: 506-37-6
Formula: C₂₄H₄₆O₂
Molecular Weight:366.62

Storage:

4°C, protect from light

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Nervonic acid Chemical Structure

CAS No.: 506-37-6

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
Publications (5)
Solvent & Solubility
- In Vitro
- In Vivo
Purity & Documentation
References
Help & FAQs
Classifications
Bioz

Biological Activity

Description

IC₅₀ & Target

Human Endogenous Metabolite

All Endogenous Metabolite Isoforms :

All NF-κB Isoforms :

In Vitro

Nervonic acid (0.01 μM, 48 h) can improve the activity of PC-12 cells and play a role as a neuroprotective mediator in the brain^[1].
Nervonic acid (12.5, 25, 50 μM, 24 h) can decrease the inflammatory response of RAW264.7 cells induced by LPS and inhibit the activation of key signal pathways related to inflammation^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[1]

Cell Line:

PC-12
Concentration:

0.001, 0.01, 0.1, 1. 10 μM
Incubation Time:

48 h
Result:

Increased cell viability pretreated with a very low concentration.

Western Blot Analysis^[3]

Cell Line:

RAW264.7
Concentration:

12.5, 25, 50 μM
Incubation Time:

24 h
Result:

Decreased the expression of TLR4, JNK, P38 and NF-κB.

In Vivo

Nervonic acid (20, 40, 60 mg/kg, gavage for 7 days) protects the motor system against motor disorders in a PD mouse model^[2].
Nervonic acid (5, 50, 100 mg/kg, dissolved in corn oil for 7 days) improves colonic inflammation by inhibiting the NF-κB signaling pathway in DSS-induced colitis mice^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

MPTP-induced PD mice model^[2]
Dosage:

20, 40, 60 mg/kg
Administration:

i.g. for 7 days
Result:

Reversed behavioral deficits inhibited the α-synuclein expression and regulated oxidative stress response.

Animal Model:

DSS-induced colitis mice model^[3]
Dosage:

5, 50, 100 mg/kg
Administration:

i.g. for 7 days
Result:

Improved the symptoms of diarrhea, weight loss and fecal occidental blood.
Reduced the levels of COX-2 and iNOS.

Chemical Information

CAS No. 506-37-6
Appearance Solid
Molecular Weight 366.62
Formula C₂₄H₄₆O₂
Color White to off-white
SMILES

CCCCCCCC/C=C\CCCCCCCCCCCCCC(O)=O
Synonyms

Selacholeic acid; cis-15-Tetracosenoic acid
Structure Classification
- Ketones, Aldehydes, Acids
Initial Source
- Plants
- other families
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, protect from light

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Publications (5)

All Cell Proliferation/Viability AssayIHCFlow CytometryWB

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Journal Impact Factor

Leukemia

Targeting ABCD1-ACOX1-MET/IGF1R axis suppresses multiple myeloma. [Abstract]

2025 Mar;39(3):720-733. PMID: 39885295
Cancer Cell Int

Stearoyl CoA desaturase inhibition can effectively induce apoptosis in bladder cancer stem cells. [Abstract]

2024 Oct 29;24(1):357. PMID: 39472909

Nervonic acid purchased from MedChemExpress. Usage Cited in: Cancer Cell Int. 2024 Oct 29;24(1):357. [Abstract]

Nervonic acid restoration counteracts UMUC3 cell proliferation reduction caused by A939572 treatment.

Nervonic acid purchased from MedChemExpress. Usage Cited in: Cancer Cell Int. 2024 Oct 29;24(1):357. [Abstract]

A939572 treatment reduced cell proliferation and Nervonic acid supplementation counteracted this effect.
Eur J Pharmacol

Nervonic acid protects against oligodendrocytes injury following chronic cerebral hypoperfusion in mice. [Abstract]

2024 Aug 23:176932. PMID: 39182543

Nervonic acid purchased from MedChemExpress. Usage Cited in: Eur J Pharmacol. 2024 Aug 23:176932. [Abstract]

Immunohistochemical visualization and quantification of CC-1+ oligodendrocyte numbers at 28 d after rUCCAO in mice administered Nervonic acid (NA: 72 mg/kg/d).

Nervonic acid purchased from MedChemExpress. Usage Cited in: Eur J Pharmacol. 2024 Aug 23:176932. [Abstract]

Viability of OPCs after treatment with Nervonic acid (NA) 5,25 and 50 μmol/L for 24 h measured by the CCK-8 test.

Nervonic acid purchased from MedChemExpress. Usage Cited in: Eur J Pharmacol. 2024 Aug 23:176932. [Abstract]

Nervonic acid (NA 5, 25 μM). Western blot analysis of expression of apoptosis-related proteins (including Bcl-2, Bax, and cleaved-Caspase-3 (c-Cas3)) in primary cultured oligodendrocytes after OGD/Rep.
J Leukoc Biol

Nervonic acid mitigates IMQ-triggered psoriasis in mice via inhibiting Th17/γδT17 cell invasion and modulating the gut microbiota. [Abstract]

2025 May 21:qiaf070. PMID: 40397706
Biochem Biophys Res Commun

Nervonic acid improves depression like behaviors and demyelination of medial prefrontal cortex in chronic restraint stress mice. [Abstract]

2024 Sep 13:733:150696. PMID: 39288700

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (272.76 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

2.7276 mL

13.6381 mL

27.2762 mL

5 mM

0.5455 mL

2.7276 mL

5.4552 mL

10 mM

0.2728 mL

1.3638 mL

2.7276 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Dilution Calculator

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

Stock Solution Working Solution

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline

Solubility: ≥ 1.67 mg/mL (4.56 mM); Clear solution

This protocol yields a clear solution of ≥ 1.67 mg/mL (saturation unknown).

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (16.7 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

Protocol 2

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)

Solubility: ≥ 1.67 mg/mL (4.56 mM); Clear solution

This protocol yields a clear solution of ≥ 1.67 mg/mL (saturation unknown).

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (16.7 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

Protocol 3

Add each solvent one by one: 10% DMSO 90% Corn Oil

Solubility: ≥ 1.67 mg/mL (4.56 mM); Clear solution

This protocol yields a clear solution of ≥ 1.67 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (16.7 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage Dosage
mg/kg
Animal Weight (Per Animal) Animal Weight (Per Animal)
g
Dosing Volume (Per Animal) Dosing Volume (Per Animal)
μL
Number of Animals Number of Animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

%
DMSO +

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
%
+
+
%
Tween-80 + +
%
Saline +

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Working solution concentration: 0.22 mg/mL

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (272 KB)
SDS (394 KB)
- English - EN (394 KB)
- Français - FR (394 KB)
- Deutsch - DE (394 KB)
- Norwegian - NO (394 KB)
- Español - ES (394 KB)
- Swedish - SV (394 KB)
- Italian - IT (394 KB)
- Korean - KR (394 KB)
- Portuguese - PT (394 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Umemoto H, et al. Protective Effect of Nervonic Acid Against 6-Hydroxydopamine-Induced Oxidative Stress in PC-12 Cells. J Oleo Sci. 2021;70(1):95-102. [Content Brief]

[2]. Hu D, et al. Nervonic acid amends motor disorder in a mouse model of Parkinson's disease. Transl Neurosci. 2022 Apr 20;13(1):71. [Content Brief]

[3]. Yuan SN, et al. Improved colonic inflammation by nervonic acid via inhibition of NF-κB signaling pathway of DSS-induced colitis mice. Phytomedicine. 2023 Apr;112:154702. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	2.7276 mL	13.6381 mL	27.2762 mL	68.1905 mL
	5 mM	0.5455 mL	2.7276 mL	5.4552 mL	13.6381 mL
	10 mM	0.2728 mL	1.3638 mL	2.7276 mL	6.8190 mL
	15 mM	0.1818 mL	0.9092 mL	1.8184 mL	4.5460 mL
	20 mM	0.1364 mL	0.6819 mL	1.3638 mL	3.4095 mL
	25 mM	0.1091 mL	0.5455 mL	1.0910 mL	2.7276 mL
	30 mM	0.0909 mL	0.4546 mL	0.9092 mL	2.2730 mL
	40 mM	0.0682 mL	0.3410 mL	0.6819 mL	1.7048 mL
	50 mM	0.0546 mL	0.2728 mL	0.5455 mL	1.3638 mL
	60 mM	0.0455 mL	0.2273 mL	0.4546 mL	1.1365 mL
	80 mM	0.0341 mL	0.1705 mL	0.3410 mL	0.8524 mL
	100 mM	0.0273 mL	0.1364 mL	0.2728 mL	0.6819 mL

Keywords

Nervonic acid

5 Cited Publications

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Nervonic acid

Immunology/Inflammation Compound Library

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Publications Citing Use of MedChemExpress (MCE) Nervonic acid

All Endogenous Metabolite Isoforms

All NF-κB Isoforms

Biological Activity

Chemical Information

Publications (5)

Solvent & Solubility

Purity & Documentation

References

Help & FAQs

Complete Stock Solution Preparation Table

Nervonic acid Related Classifications

HY-N2526 Related Classifications