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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
12 Results for "
TPM3
" in MedChemExpress (MCE) Product Catalog:
Products (12)
12 Results for "TPM3" in MCE Product Catalog:
Cat. No.: HY-137465
CAS No.: 2412055-93-5
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CG428 is a potent and selective CRBN-dependent tropomyosin receptor kinase (TRK) PROTAC degrader that has anti-tumor activity. CG428 reduces levels of the tropomyosin 3 TPM3-TRKA fusion protein in KM12 colorectal carcinoma cells (DC50 = 0.36 nM) and inhibits downstream PLCγ1 phosphorylation (IC50 = 0.33 nM). CG428 has a higher binding affinity for TRKA than TRKB and TRKC (Kd = 1 nM, 28 nM and 4.2 nM, respectively). CG428 can be used for the research of colorectal carcinoma .
Cat. No.: HY-157542
CAS No.: 2714560-39-9
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CG428-NEG is the negative control of PROTAC CG428 (HY-137465). CG428-NEG binds to TRKA, TRKB and TRKC with high affinity, with Kd values of 0.88 nM, 4.8 nM and 59.8 nM, respectively. CG428-NEG inhibits the growth of cancer cells and reduces the level of TPM3-TRKA fusion protein in cancer cells. CG428-NEG can be used in the research of colorectal cancer .
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TR-100 is a small molecule inhibitor of tumor-associated troponin (Tpm). TR-100 affects the interaction of Tpm3.1 with actin filaments by binding to the C-terminal of Tpm3.1, thereby affecting the stability and function of the actin filaments. This mechanism of action allows TR-100 to specifically affect actin filaments in cancer cells without compromising heart muscle function. TR-100 can be used to study the role of Tpm3.1 in cancer cell proliferation and survival and the effects of Tpm3.1 on insulin-stimulated glucose uptake and insulin secretion .
Cat. No.: HY-RS14938
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TPM3 Human Pre-designed siRNA Set A contains three designed siRNAs for TPM3 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS18503
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Tpm3 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Tpm3 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS24985
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Tpm3 Rat Pre-designed siRNA Set A contains three designed siRNAs for Tpm3 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-131244
CAS No.: 2359662-39-6
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ALK-IN-9 (compound 40) is a potent ALK inhibitor. ALK-IN-9 inhibits cell proliferation with IC50s of <0.2 nM, <0.2 nM, 0.2 nM for Ba/F3-EML4-ALK, KM 12 (TPM3-TRKA), KG-l cell (OP2-FGFR1), respectively .
Cat. No.: HY-175271
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JWJ-01-378 is a TPM3-TRKA fusion protein inhibitor and a wild-type TRK PROTAC degrader. JWJ-01-378 induces degradation via the ubiquitin-proteasome system, and does not degrade TRK inhibitor-resistant mutants or ALK fusion proteins. JWJ-01-378 inhibits downstream signaling pathways activated by TPM3-TRKA fusion, and reduces the viability of cancer cells harboring TPM3-TRKA fusion. JWJ-01-378 can be used to evaluate targeted degradation of TRK fusion proteins in cancer .
Cat. No.: HY-164514
CAS No.: 942471-37-6
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NMS-P626 is an inhibitor of TRKA, TRKB, and TRKC, with IC50 values of 8 nM, 7 nM, and 3 nM, respectively. NMS-P626 inhibits the growth of KM12 cells by suppressing the phosphorylation of TPM3-TRKA and downstream signaling in KM12 cells, with an IC50 of 19 nM for KM12 cells. NMS-P626 can be used in colorectal cancer research .
Cat. No.: HY-P71083
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: TPM3; Tropomyosin-3; Prev. NEM1; OK/SW-Cl.5; TRK; HEL-S-82p; Tropomyosin Alpha-3 Chain; HEL-189; Tropomyosin-5; CMYO4A; TPM3nu; CMYO4B; CDNA FLJ32435 Fis, Clone SKMUS2001287, Highly Similar To Tropomyosin Alpha-3 Chain; CMYP4A; Epididymis Secretory Sperm
Species:
Human
Source:
E. coli
Cat. No.: HY-P810812
Synonyms: Tropomyosin alpha-3 chain, Gamma-tropomyosin, Tropomyosin-3, Tropomyosin-5, hTM5, TPM3
Cat. No.: HY-P72264
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: TPM2; Arthrogryposis Multiplex Congenital, Distal, Type 1; Prev. AMCD1; Beta-Tropomyosin; NEM4; Tropomyosin-2; DA1; HEL-S-273; Epididymis Secretory Protein Li 273; CMYP23; Nemaline Myopathy Type 4; CMYO23; Tropomyosin Beta Chain; DA2B4; Tropomyosin 2 (Bet
Species:
Human
Source:
E. coli
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
