1128165-86-5
Chemical Structure
TR-100
- CAS No.: 1128165-86-5
- Formula:C26H38N4O
- Molecular Weight:422.61
IUPAC Name: (E)-2-cyano-3-(1-(3-(dimethylamino)propyl)-2-methyl-1H-indol-3-yl)-N-octylacrylamide
InChIKey: XXRLIGWROLDOLS-ZBJSNUHESA-N
SMILES: O=C(NCCCCCCCC)/C(C#N)=C/C1=C(C)N(CCCN(C)C)C2=C1C=CC=C2
Biological Activity: TR-100 is a Tpm3.1 inhibitor that binds to and disrupts Tpm3.1-containing Actin filaments, enhancing the depolymerizing effect of Tpm3.1 on actin without altering actin-tropomyosin binding. TR-100 induces actin cytoskeleton rearrangement. TR-100 shortens membrane nanotubes and alters tube thickness in a concentration-dependent manner. TR-100 increases basal insulin secretion and inhibits glucose-stimulated insulin secretion. TR-100 inhibits insulin-stimulated glucose uptake. TR-100 can be used for research on B lymphoma[1][2].
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TR-100 | 99.0% | TR-100 is a Tpm3.1 inhibitor that binds to and disrupts Tpm3.1-containing Actin filaments, enhancing the depolymerizing effect of Tpm3.1 on actin without altering actin-tropomyosin binding. TR-100 induces actin cytoskeleton rearrangement. TR-100 shortens membrane nanotubes and alters tube thickness in a concentration-dependent manner. TR-100 increases basal insulin secretion and inhibits glucose-stimulated insulin secretion. TR-100 inhibits insulin-stimulated glucose uptake. TR-100 can be used for research on B lymphoma. | ||||||||||||||||||||
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References
- [1]. Hencz A J, et al. Visualization of the effect of TR100 anti-cancer compound on membrane nanotubes with SR-SIM microscopy[J]. Resolution and Discovery, 2022, 6(1): 12-19.
- [2]. Kee AJ, et al. On-target action of anti-tropomyosin drugs regulates glucose metabolism. Scientific reports. 2018 Mar 15;8(1):4604. [Content Brief]
