1128165-86-5
Chemical Structure
TR-100
- CAS No.: 1128165-86-5
- Formula:C26H38N4O
- Molecular Weight:422.61
IUPAC Name: (E)-2-cyano-3-(1-(3-(dimethylamino)propyl)-2-methyl-1H-indol-3-yl)-N-octylacrylamide
InChIKey: XXRLIGWROLDOLS-ZBJSNUHESA-N
SMILES: O=C(NCCCCCCCC)/C(C#N)=C/C1=C(C)N(CCCN(C)C)C2=C1C=CC=C2
Biological Activity: TR-100 is a small molecule inhibitor of tumor-associated troponin (Tpm). TR-100 affects the interaction of Tpm3.1 with actin filaments by binding to the C-terminal of Tpm3.1, thereby affecting the stability and function of the actin filaments. This mechanism of action allows TR-100 to specifically affect actin filaments in cancer cells without compromising heart muscle function. TR-100 can be used to study the role of Tpm3.1 in cancer cell proliferation and survival and the effects of Tpm3.1 on insulin-stimulated glucose uptake and insulin secretion[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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TR-100 | 99.0% | TR-100 is a small molecule inhibitor of tumor-associated troponin (Tpm). TR-100 affects the interaction of Tpm3.1 with actin filaments by binding to the C-terminal of Tpm3.1, thereby affecting the stability and function of the actin filaments. This mechanism of action allows TR-100 to specifically affect actin filaments in cancer cells without compromising heart muscle function. TR-100 can be used to study the role of Tpm3.1 in cancer cell proliferation and survival and the effects of Tpm3.1 on insulin-stimulated glucose uptake and insulin secretion. | ||||||||||||||||||||
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- [1]. Hill T A, et al. Inhibition of Dynamin Mediated Endocytosis by the Dynoles--Synthesis and Functional Activity of a Family of Indoles[J]. Journal of medicinal chemistry, 2009, 52(12): 3762-3773. [Content Brief]
- [2]. Kee A J, et al. On-target action of anti-tropomyosin drugs regulates glucose metabolism[J]. Scientific reports, 2018, 8(1): 4604. [Content Brief]
Keywords
