3-beta-hydroxysteroid-Delta

Definition:

Catalyzes the conversion of Delta(8)-sterols to their corresponding Delta(7)-isomers.

References:

[1]. F F Moebius, et al. Histidine77, glutamic acid81, glutamic acid123, threonine126, asparagine194, and tryptophan197 of the human emopamil binding protein are required for in vivo sterol delta 8-delta 7 isomerization. Biochemistry. 1999 Jan 19;38(3):1119-27. [Content Brief]

[2]. Fabian F Moebius, et al. Cloning of an emopamil-binding protein (EBP)-like protein that lacks sterol delta8-delta7 isomerase activity. Biochem J. 2003 Aug 15;374(Pt 1):229-37. [Content Brief]

[3]. S Silve, et al. Emopamil-binding protein, a mammalian protein that binds a series of structurally diverse neuroprotective agents, exhibits delta8-delta7 sterol isomerase activity in yeast. J Biol Chem. 1996 Sep 13;271(37):22434-40. [Content Brief]

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