3-hydroxy-3-methylglutaryl-coenzyme A reductase
Definition:
References:
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[1]. E S Istvan, et al. Structural mechanism for statin inhibition of HMG-CoA reductase. Science. 2001 May 11;292(5519):1160-4. [Content Brief]
[2]. M S Brown, et al. Multivalent feedback regulation of HMG CoA reductase, a control mechanism coordinating isoprenoid synthesis and cell growth. J Lipid Res. 1980 Jul;21(5):505-17. [Content Brief]
[3]. Massimiliano Cuccioloni, et al. Epigallocatechin-3-gallate potently inhibits the in vitro activity of hydroxy-3-methyl-glutaryl-CoA reductase. J Lipid Res. 2011 May;52(5):897-907. [Content Brief]
[4]. Ronald W Sarver, et al. Thermodynamic and structure guided design of statin based inhibitors of 3-hydroxy-3-methylglutaryl coenzyme A reductase. J Med Chem. 2008 Jul 10;51(13):3804-13. [Content Brief]
[5]. K L Luskey, et al. Human 3-hydroxy-3-methylglutaryl coenzyme A reductase. Conserved domains responsible for catalytic activity and sterol-regulated degradation. J Biol Chem. 1985 Aug 25;260(18):10271-7. [Content Brief]
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