ABC-type oligopeptide transporter ABCB9

Definition:

ATP-dependent low-affinity peptide transporter which translocates a broad spectrum of peptides from the cytosol to the lysosomal lumen for degradation. Displays a broad peptide length specificity from 6-mer up to at least 59-mer peptides with an optimum of 23-mers. Binds and transports smaller and larger peptides with the same affinity. Favors positively charged, aromatic or hydrophobic residues in the N- and C-terminal positions whereas negatively charged residues as well as asparagine and methionine are not favored.

References:

[1]. Tina Zollmann, et al. Single liposome analysis of peptide translocation by the ABC transporter TAPL. Proc Natl Acad Sci U S A. 2015 Feb 17;112(7):2046-51. [Content Brief]

[2]. Chenguang Zhao, et al. Peptide specificity and lipid activation of the lysosomal transport complex ABCB9 (TAPL). J Biol Chem. 2008 Jun 20;283(25):17083-91. [Content Brief]

[3]. Ozlem Demirel, et al. Identification of a lysosomal peptide transport system induced during dendritic cell development. J Biol Chem. 2007 Dec 28;282(52):37836-43. [Content Brief]

[4]. Özlem Demirel, et al. The lysosomal polypeptide transporter TAPL is stabilized by interaction with LAMP-1 and LAMP-2. J Cell Sci. 2012 Sep 15;125(Pt 18):4230-40. [Content Brief]

[5]. Philipp Graab, et al. Lysosomal targeting of the ABC transporter TAPL is determined by membrane-localized charged residues. J Biol Chem. 2019 May 3;294(18):7308-7323. [Content Brief]

[6]. Christoph Bock, et al. Structural and functional insights into the interaction and targeting hub TMD0 of the polypeptide transporter TAPL. Sci Rep. 2018 Oct 23;8(1):15662. [Content Brief]

[7]. Christoph Bock, et al. Peptide translocation by the lysosomal ABC transporter TAPL is regulated by coupling efficiency and activation energy. Sci Rep. 2019 Aug 15;9(1):11884. [Content Brief]

[8]. Justina Clarinda Wolters, et al. Selective and ATP-dependent translocation of peptides by the homodimeric ATP binding cassette transporter TAP-like (ABCB9). J Biol Chem. 2005 Jun 24;280(25):23631-6. [Content Brief]

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