Acetylcholine receptor subunit alpha
Definition:
[Isoform 1]: Upon acetylcholine binding, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.; [Isoform 2]: Non functional acetylcholine receptor alpha subunit which is not integrated into functional acetylcholine-gated cation-selective channels.
References:
-
[1]. C F Newland, et al. Functional and non-functional isoforms of the human muscle acetylcholine receptor. J Physiol. 1995 Dec 15;489 ( Pt 3)(Pt 3):767-78. [Content Brief]
[2]. Xin-Ming Shen, et al. Mutations Causing Slow-Channel Myasthenia Reveal That a Valine Ring in the Channel Pore of Muscle AChR is Optimized for Stabilizing Channel Gating. Hum Mutat. 2016 Oct;37(10):1051-9. [Content Brief]
Biomedical Dictionary
The Biomedical Dictionary is a comprehensive and professional collection of biological academic terms and subject datas. All explanations are supported by authoritative books or high impact factor literatures, and you can acquire accurate explanations of the biomedical terms you want to know.
Molarity Calculator
Dilution Calculator
