Activin receptor type-2A

Definition:

On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for activin A, activin B and inhibin A. Mediates induction of adipogenesis by GDF6 (By similarity).

References:

[1]. C J Donaldson, et al. Molecular cloning and binding properties of the human type II activin receptor. Biochem Biophys Res Commun. 1992 Apr 15;184(1):310-6. [Content Brief]

[2]. Nina Renlund, et al. Activin receptor-like kinase-2 inhibits activin signaling by blocking the binding of activin to its type II receptor. J Endocrinol. 2007 Oct;195(1):95-103. [Content Brief]

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