Acute alcohol sensitivity
Definition:
Aldehyde dehydrogenases (ALDHs) are important enzymes that eliminate toxic aldehydes by catalysing their oxidation to non-reactive acids. It is reported that a deficiency in the ALDH2 is associated with the alcohol flush reaction. More than 40% of the East Asians population carries a common ALDH2 mutant allele, which results in a dramatic reduction in the enzymatic activity when compared with the wild-type allele.
References:
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[1]. Che-Hong Chen, et al. Mitochondrial aldehyde dehydrogenase and cardiac diseases. Cardiovasc Res. 2010 Oct 1;88(1):51-7. [Content Brief]
[2]. Peter A Dickson, et al. Effects of variation at the ALDH2 locus on alcohol metabolism, sensitivity, consumption, and dependence in Europeans. Alcohol Clin Exp Res. 2006 Jul;30(7):1093-100. [Content Brief]
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