Acyl-coenzyme A thioesterase 13
Definition:
Catalyzes the hydrolysis of acyl-CoAs into free fatty acids and coenzyme A (CoASH), regulating their respective intracellular levels. Has acyl-CoA thioesterase activity towards medium (C12) and long-chain (C18) fatty acyl-CoA substrates (By similarity). Can also hydrolyze 3-hydroxyphenylacetyl-CoA and 3,4-dihydroxyphenylacetyl-CoA (in vitro) (By similarity). May play a role in controlling adaptive thermogenesis (By similarity).
References:
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[1]. Zhongjun Cheng, et al. Crystal structure of human thioesterase superfamily member 2. Biochem Biophys Res Commun. 2006 Oct 13;349(1):172-7. [Content Brief]
[2]. Jian Cao, et al. The mechanisms of human hotdog-fold thioesterase 2 (hTHEM2) substrate recognition and catalysis illuminated by a structure and function based analysis. Biochemistry. 2009 Feb 17;48(6):1293-304. [Content Brief]
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