Aminoacyl tRNA synthase complex-interacting multifunctional protein 2
Definition:
Required for assembly and stability of the aminoacyl-tRNA synthase complex. Mediates ubiquitination and degradation of FUBP1, a transcriptional activator of MYC, leading to MYC down-regulation which is required for aveolar type II cell differentiation. Blocks MDM2-mediated ubiquitination and degradation of p53/TP53. Functions as a proapoptotic factor.
References:
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[1]. Monika Kaminska, et al. Dissection of the structural organization of the aminoacyl-tRNA synthetase complex. J Biol Chem. 2009 Mar 6;284(10):6053-60. [Content Brief]
[2]. Han Seok Ko, et al. Accumulation of the authentic parkin substrate aminoacyl-tRNA synthetase cofactor, p38/JTV-1, leads to catecholaminergic cell death. J Neurosci. 2005 Aug 31;25(35):7968-78. [Content Brief]
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