Ankyrin repeat domain-containing protein 49

Definition:

Induces HBG1 expression. May have a role in spermatogenesis where it promotes autophagy in response to serum starvation, via the NF-kappaB pathway (By similarity).

References:

[1]. C Anthony Blau, et al. {gamma}-Globin gene expression in chemical inducer of dimerization (CID)-dependent multipotential cells established from human {beta}-globin locus yeast artificial chromosome ({beta}-YAC) transgenic mice. J Biol Chem. 2005 Nov 4;280(44):36642-7. [Content Brief]

[2]. Y Yang, et al. Cloning and characterization of a potential transcriptional activator of human gamma-globin genes. Blood Cells Mol Dis. 2001 Jan-Feb;27(1):1-15. [Content Brief]

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