antibody-dependent cellular cytotoxicity (ADCC)

Definition:

Antibody-dependent cell-mediated cytotoxicity (ADCC) refers to the direct killing of target cells by lethal cells such as Natural killer cells (NKs), which recognize the Fc segment of antibody coated on target antigen through Fc receptors (FcRs) expressed by NK cells.

References:

[1]. Luqman M, et al. The antileukemia activity of a human anti-CD40 antagonist antibody, HCD122, on human chronic lymphocytic leukemia cells. Blood. 2008 Aug 1;112(3):711-20. [Content Brief]

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