Broad substrate specificity ATP-binding cassette transporter ABCG2

[1]. H Komatani, et al. Identification of breast cancer resistant protein/mitoxantrone resistance/placenta-specific, ATP-binding cassette transporter as a transporter of NB-506 and J-107088, topoisomerase I inhibitors with an indolocarbazole structure. Cancer Res. 2001 Apr 1;61(7):2827-32. [Content Brief]

[2]. Nicholas M I Taylor, et al. Structure of the human multidrug transporter ABCG2. Nature. 2017 Jun 22;546(7659):504-509. [Content Brief]

[3]. Michiko Suzuki, et al. ABCG2 transports sulfated conjugates of steroids and xenobiotics. J Biol Chem. 2003 Jun 20;278(25):22644-9. [Content Brief]

[4]. Wandong Zhang, et al. The expression and functional characterization of ABCG2 in brain endothelial cells and vessels. FASEB J. 2003 Nov;17(14):2085-7. [Content Brief]

[5]. Ioannis Manolaridis, et al. Cryo-EM structures of a human ABCG2 mutant trapped in ATP-bound and substrate-bound states. Nature. 2018 Nov;563(7731):426-430. [Content Brief]

[6]. Kazuaki Takabe, et al. Estradiol induces export of sphingosine 1-phosphate from breast cancer cells via ABCC1 and ABCG2. J Biol Chem. 2010 Apr 2;285(14):10477-86. [Content Brief]

[7]. Elodie Desuzinges-Mandon, et al. ABCG2 transports and transfers heme to albumin through its large extracellular loop. J Biol Chem. 2010 Oct 22;285(43):33123-33133. [Content Brief]

[8]. Yu Toyoda, et al. Functional Characterization of Clinically-Relevant Rare Variants in ABCG2 Identified in a Gout and Hyperuricemia Cohort. Cells. 2019 Apr 18;8(4):363. [Content Brief]

[9]. Boglárka Zámbó, et al. Cellular expression and function of naturally occurring variants of the human ABCG2 multidrug transporter. Cell Mol Life Sci. 2020 Jan;77(2):365-378. [Content Brief]

[10]. Owen M Woodward, et al. Identification of a urate transporter, ABCG2, with a common functional polymorphism causing gout. Proc Natl Acad Sci U S A. 2009 Jun 23;106(25):10338-42. [Content Brief]

[11]. Hirotsugu Kobuchi, et al. Mitochondrial localization of ABC transporter ABCG2 and its function in 5-aminolevulinic acid-mediated protoporphyrin IX accumulation. PLoS One. 2012;7(11):e50082. [Content Brief]

[12]. Hirotaka Matsuo, et al. Common defects of ABCG2, a high-capacity urate exporter, cause gout: a function-based genetic analysis in a Japanese population. Sci Transl Med. 2009 Nov 4;1(5):5ra11. [Content Brief]

[13]. Akiyoshi Nakayama, et al. ABCG2 is a high-capacity urate transporter and its genetic impairment increases serum uric acid levels in humans. Nucleosides Nucleotides Nucleic Acids. 2011 Dec;30(12):1091-7. [Content Brief]

[14]. Csilla Ozvegy-Laczka, et al. Single amino acid (482) variants of the ABCG2 multidrug transporter: major differences in transport capacity and substrate recognition. Biochim Biophys Acta. 2005 Feb 1;1668(1):53-63. [Content Brief]

[15]. Yingqiu Xie, et al. The 44-kDa Pim-1 kinase phosphorylates BCRP/ABCG2 and thereby promotes its multimerization and drug-resistant activity in human prostate cancer cells. J Biol Chem. 2008 Feb 8;283(6):3349-3356. [Content Brief]

[16]. John D Allen, et al. Potent and specific inhibition of the breast cancer resistance protein multidrug transporter in vitro and in mouse intestine by a novel analogue of fumitremorgin C. Mol Cancer Ther. 2002 Apr;1(6):417-25. [Content Brief]