Caspase-14

Definition:

Non-apoptotic caspase involved in epidermal differentiation. Is the predominant caspase in epidermal stratum corneum. Seems to play a role in keratinocyte differentiation and is required for cornification. Regulates maturation of the epidermis by proteolytically processing filaggrin (By similarity). In vitro has a preference for the substrate [WY]-X-X-D motif and is active on the synthetic caspase substrate WEHD-ACF. Involved in processing of prosaposin in the epidermis (By similarity). May be involved in retinal pigment epithelium cell barrier function. Involved in DNA degradation in differentiated keratinocytes probably by cleaving DFFA/ICAD leading to liberation of DFFB/CAD.

References:

[1]. Heinz Fischer, et al. Stratum corneum-derived caspase-14 is catalytically active. FEBS Lett. 2004 Nov 19;577(3):446-50. [Content Brief]

[2]. Jowita Mikolajczyk, et al. Activation and substrate specificity of caspase-14. Biochemistry. 2004 Aug 17;43(32):10560-9. [Content Brief]

[3]. Kyewhan Park, et al. Expression and characterization of constitutively active human caspase-14. Biochem Biophys Res Commun. 2006 Sep 8;347(4):941-8. [Content Brief]

[4]. M Yamamoto-Tanaka, et al. Multiple pathways are involved in DNA degradation during keratinocyte terminal differentiation. Cell Death Dis. 2014 Apr 17;5(4):e1181. [Content Brief]

[5]. Selina Beasley, et al. Caspase-14 expression impairs retinal pigment epithelium barrier function: potential role in diabetic macular edema. Biomed Res Int. 2014;2014:417986. [Content Brief]

[6]. Toshihiko Hibino, et al. Purification and characterization of active caspase-14 from human epidermis and development of the cleavage site-directed antibody. J Cell Biochem. 2010 Feb 15;109(3):487-97. [Content Brief]

[7]. Mami Yamamoto, et al. Kallikrein-related peptidase-7 regulates caspase-14 maturation during keratinocyte terminal differentiation by generating an intermediate form. J Biol Chem. 2012 Sep 21;287(39):32825-34. [Content Brief]

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