Caspase-5
Definition:
Thiol protease that acts as a mediator of programmed cell death. Initiates pyroptosis, a programmed lytic cell death pathway through cleavage of Gasdermin-D (GSDMD): cleavage releases the N-terminal gasdermin moiety (Gasdermin-D, N-terminal) that binds to membranes and forms pores, triggering pyroptosis. During non-canonical inflammasome activation, cuts CGAS and may play a role in the regulation of antiviral innate immune activation.
References:
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[1]. Estefania Mulvihill, et al. Mechanism of membrane pore formation by human gasdermin-D. EMBO J. 2018 Jul 13;37(14):e98321. [Content Brief]
[2]. Yutao Wang, et al. Inflammasome Activation Triggers Caspase-1-Mediated Cleavage of cGAS to Regulate Responses to DNA Virus Infection. Immunity. 2017 Mar 21;46(3):393-404. [Content Brief]
Biomedical Dictionary
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