Cell cycle checkpoint protein RAD17

Definition:

Essential for sustained cell growth, maintenance of chromosomal stability, and ATR-dependent checkpoint activation upon DNA damage. Has a weak ATPase activity required for binding to chromatin. Participates in the recruitment of the RAD1-RAD9-HUS1 complex and RHNO1 onto chromatin, and in CHEK1 activation. May also serve as a sensor of DNA replication progression, and may be involved in homologous recombination.

References:

[1]. Xin Wang, et al. Genomic instability and endoreduplication triggered by RAD17 deletion. Genes Dev. 2003 Apr 15;17(8):965-70. [Content Brief]

[2]. S Bao, et al. ATR/ATM-mediated phosphorylation of human Rad17 is required for genotoxic stress responses. Nature. 2001 Jun 21;411(6840):969-74. [Content Brief]

[3]. Lee Zou, et al. Regulation of ATR substrate selection by Rad17-dependent loading of Rad9 complexes onto chromatin. Genes Dev. 2002 Jan 15;16(2):198-208. [Content Brief]

[4]. Cheng-Chung Tsao, et al. Interaction between human MCM7 and Rad17 proteins is required for replication checkpoint signaling. EMBO J. 2004 Nov 24;23(23):4660-9. [Content Brief]

[5]. L Li, et al. hRAD17, a structural homolog of the Schizosaccharomyces pombe RAD17 cell cycle checkpoint gene, stimulates p53 accumulation. Oncogene. 1999 Mar 4;18(9):1689-99. [Content Brief]

[6]. Cecilia Cotta-Ramusino, et al. A DNA damage response screen identifies RHINO, a 9-1-1 and TopBP1 interacting protein required for ATR signaling. Science. 2011 Jun 10;332(6035):1313-7. [Content Brief]

[7]. Viola Ellison, et al. Biochemical characterization of DNA damage checkpoint complexes: clamp loader and clamp complexes with specificity for 5' recessed DNA. PLoS Biol. 2003 Nov;1(2):E33. [Content Brief]

[8]. Vladimir P Bermudez, et al. Loading of the human 9-1-1 checkpoint complex onto DNA by the checkpoint clamp loader hRad17-replication factor C complex in vitro. Proc Natl Acad Sci U S A. 2003 Feb 18;100(4):1633-8. [Content Brief]

[9]. S Post, et al. Phosphorylation of serines 635 and 645 of human Rad17 is cell cycle regulated and is required for G(1)/S checkpoint activation in response to DNA damage. Proc Natl Acad Sci U S A. 2001 Nov 6;98(23):13102-7. [Content Brief]

[10]. Renu Garg, et al. Chromatin association of rad17 is required for an ataxia telangiectasia and rad-related kinase-mediated S-phase checkpoint in response to low-dose ultraviolet radiation. Mol Cancer Res. 2004 Jun;2(6):362-9. [Content Brief]

[11]. Sean M Post, et al. The human checkpoint Rad protein Rad17 is chromatin-associated throughout the cell cycle, localizes to DNA replication sites, and interacts with DNA polymerase epsilon. Nucleic Acids Res. 2003 Oct 1;31(19):5568-75. [Content Brief]

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