Cell division cycle-associated 7-like protein

Definition:

Plays a role in transcriptional regulation as a repressor that inhibits monoamine oxidase A (MAOA) activity and gene expression by binding to the promoter. Plays an important oncogenic role in mediating the full transforming effect of MYC in medulloblastoma cells. Involved in apoptotic signaling pathways; May act downstream of P38-kinase and BCL-2, but upstream of CASP3/caspase-3 as well as CCND1/cyclin D1 and E2F1.

References:

[1]. Kevin Chen, et al. R1, a novel repressor of the human monoamine oxidase A. J Biol Chem. 2005 Mar 25;280(12):11552-9. [Content Brief]

[2]. Xiao-Ming Ou, et al. Monoamine oxidase A and repressor R1 are involved in apoptotic signaling pathway. Proc Natl Acad Sci U S A. 2006 Jul 18;103(29):10923-8. [Content Brief]

[3]. Annie Huang, et al. Identification of a novel c-Myc protein interactor, JPO2, with transforming activity in medulloblastoma cells. Cancer Res. 2005 Jul 1;65(13):5607-19. [Content Brief]

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