Centromere protein H

Definition:

Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation. The CENPA-NAC complex recruits the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into centromeres. Required for chromosome congression and efficiently align the chromosomes on a metaphase plate.

References:

[1]. Richard Saffery, et al. Transcription within a functional human centromere. Mol Cell. 2003 Aug;12(2):509-16. [Content Brief]

[2]. Sandra Orthaus, et al. RNAi knockdown of human kinetochore protein CENP-H. Biochem Biophys Res Commun. 2006 Sep 15;348(1):36-46. [Content Brief]

[3]. Sarah E McClelland, et al. The CENP-A NAC/CAD kinetochore complex controls chromosome congression and spindle bipolarity. EMBO J. 2007 Dec 12;26(24):5033-47. [Content Brief]

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