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Cyclin-Y

Definition:

Positive regulatory subunit of the cyclin-dependent kinases CDK14/PFTK1 and CDK16. Acts as a cell-cycle regulator of Wnt signaling pathway during G2/M phase by recruiting CDK14/PFTK1 to the plasma membrane and promoting phosphorylation of LRP6, leading to the activation of the Wnt signaling pathway. Recruits CDK16 to the plasma membrane. Isoform 3 might play a role in the activation of MYC-mediated transcription.

References:

[1]. Gary Davidson, et al. Cell cycle control of wnt receptor activation. Dev Cell. 2009 Dec;17(6):788-99. [Content Brief]

[2]. Mei Jiang, et al. Cyclin Y, a novel membrane-associated cyclin, interacts with PFTK1. FEBS Lett. 2009 Jul 7;583(13):2171-8. [Content Brief]

[3]. Xuanyang Li, et al. Identification and characterization of cyclin X which activates transcriptional activities of c-Myc. Mol Biol Rep. 2009 Jan;36(1):97-103. [Content Brief]

[4]. Petra Mikolcevic, et al. Cyclin-dependent kinase 16/PCTAIRE kinase 1 is activated by cyclin Y and is essential for spermatogenesis. Mol Cell Biol. 2012 Feb;32(4):868-79. [Content Brief]

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