Cytoskeleton-associated protein 4

Definition:

Mediates the anchoring of the endoplasmic reticulum to microtubules.; High-affinity epithelial cell surface receptor for the FZD8-related low molecular weight sialoglycopeptide APF/antiproliferative factor. Mediates the APF antiproliferative signaling within cells.

References:

[1]. Cécile Vedrenne, et al. Phosphorylation controls CLIMP-63-mediated anchoring of the endoplasmic reticulum to microtubules. Mol Biol Cell. 2005 Apr;16(4):1928-37. [Content Brief]

[2]. Sonia L Planey, et al. Palmitoylation of cytoskeleton associated protein 4 by DHHC2 regulates antiproliferative factor-mediated signaling. Mol Biol Cell. 2009 Mar;20(5):1454-63. [Content Brief]

[3]. Thomas P Conrads, et al. CKAP4/p63 is a receptor for the frizzled-8 protein-related antiproliferative factor from interstitial cystitis patients. J Biol Chem. 2006 Dec 8;281(49):37836-43. [Content Brief]

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