ELMO domain-containing protein 2
Definition:
Acts as a GTPase-activating protein (GAP) toward guanine nucleotide exchange factors like ARL2, ARL3, ARF1 and ARF6, but not for GTPases outside the Arf family. Regulates IFN-related antiviral responses.
References:
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[1]. J Bradford Bowzard, et al. ELMOD2 is an Arl2 GTPase-activating protein that also acts on Arfs. J Biol Chem. 2007 Jun 15;282(24):17568-80. [Content Brief]
[2]. Ville Pulkkinen, et al. ELMOD2, a candidate gene for idiopathic pulmonary fibrosis, regulates antiviral responses. FASEB J. 2010 Apr;24(4):1167-77. [Content Brief]
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