Epidermal growth factor-like protein 7

Definition:

Regulates vascular tubulogenesis in vivo. Inhibits platelet-derived growth factor (PDGF)-BB-induced smooth muscle cell migration and promotes endothelial cell adhesion to the extracellular matrix and angiogenesis.

References:

[1]. Iva Nikolic, et al. EGFL7 ligates αvβ3 integrin to enhance vessel formation. Blood. 2013 Apr 11;121(15):3041-50. [Content Brief]

[2]. Marta S Charpentier, et al. CASZ1 promotes vascular assembly and morphogenesis through the direct regulation of an EGFL7/RhoA-mediated pathway. Dev Cell. 2013 Apr 29;25(2):132-43. [Content Brief]

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