Eukaryotic translation initiation factor 4E-binding protein 1

Definition:

Repressor of translation initiation that regulates EIF4E activity by preventing its assembly into the eIF4F complex: hypophosphorylated form competes with EIF4G1/EIF4G3 and strongly binds to EIF4E, leading to repress translation. In contrast, hyperphosphorylated form dissociates from EIF4E, allowing interaction between EIF4G1/EIF4G3 and EIF4E, leading to initiation of translation. Mediates the regulation of protein translation by hormones, growth factors and other stimuli that signal through the MAP kinase and mTORC1 pathways.

References:

[1]. Akiko Yanagiya, et al. Translational homeostasis via the mRNA cap-binding protein, eIF4E. Mol Cell. 2012 Jun 29;46(6):847-58. [Content Brief]

[2]. A Pause, et al. Insulin-dependent stimulation of protein synthesis by phosphorylation of a regulator of 5'-cap function. Nature. 1994 Oct 27;371(6500):762-7. [Content Brief]

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