Gamma-secretase subunit PEN-2
Definition:
References:
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[1]. Dieter Edbauer, et al. Reconstitution of gamma-secretase activity. Nat Cell Biol. 2003 May;5(5):486-8. [Content Brief]
[2]. Guanghui Yang, et al. Structural basis of Notch recognition by human γ-secretase. Nature. 2019 Jan;565(7738):192-197. [Content Brief]
[3]. Rui Zhou, et al. Recognition of the amyloid precursor protein by human γ-secretase. Science. 2019 Feb 15;363(6428):eaaw0930. [Content Brief]
[4]. Wen-jie Luo, et al. PEN-2 and APH-1 coordinately regulate proteolytic processing of presenilin 1. J Biol Chem. 2003 Mar 7;278(10):7850-4. [Content Brief]
[5]. Laura Marlow, et al. APH1, PEN2, and Nicastrin increase Abeta levels and gamma-secretase activity. Biochem Biophys Res Commun. 2003 Jun 6;305(3):502-9. [Content Brief]
[6]. W Taylor Kimberly, et al. Gamma-secretase is a membrane protein complex comprised of presenilin, nicastrin, Aph-1, and Pen-2. Proc Natl Acad Sci U S A. 2003 May 27;100(11):6382-7. [Content Brief]
[7]. Oliver Holmes, et al. Pen-2 is essential for γ-secretase complex stability and trafficking but partially dispensable for endoproteolysis. Biochemistry. 2014 Jul 15;53(27):4393-406. [Content Brief]
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