Hedgehog-interacting protein

Definition:

Modulates hedgehog signaling in several cell types including brain and lung through direct interaction with members of the hedgehog family.

References:

[1]. S Pathi, et al. Comparative biological responses to human Sonic, Indian, and Desert hedgehog. Mech Dev. 2001 Aug;106(1-2):107-17. [Content Brief]

[2]. Ivan Bosanac, et al. The structure of SHH in complex with HHIP reveals a recognition role for the Shh pseudo active site in signaling. Nat Struct Mol Biol. 2009 Jul;16(7):691-7. [Content Brief]

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