Histone deacetylase complex subunit SAP30L

Definition:

[Isoform 1]: Functions as transcription repressor, probably via its interaction with histone deacetylase complexes. Involved in the functional recruitment of the class 1 Sin3-histone deacetylase complex (HDAC) to the nucleolus. Binds DNA, apparently without sequence-specificity, and bends bound double-stranded DNA. Binds phosphoinositol phosphates (phosphoinositol 3-phosphate, phosphoinositol 4-phosphate and phosphoinositol 5-phosphate) via the same basic sequence motif that mediates DNA binding and nuclear import.; [Isoform 2]: Functions as transcription repressor; isoform 2 has lower transcription repressor activity than isoform 1 and isoform 3.; [Isoform 3]: Functions as transcription repressor; its activity is marginally lower than that of isoform 1.

References:

[1]. Hanna Korkeamäki, et al. Alternative mRNA splicing of SAP30L regulates its transcriptional repression activity. FEBS Lett. 2008 Jan 23;582(2):379-84. [Content Brief]

[2]. K M Viiri, et al. SAP30L interacts with members of the Sin3A corepressor complex and targets Sin3A to the nucleolus. Nucleic Acids Res. 2006 Jul 4;34(11):3288-98. [Content Brief]

[3]. Mikko Laitaoja, et al. Redox-dependent disulfide bond formation in SAP30L corepressor protein: Implications for structure and function. Protein Sci. 2016 Mar;25(3):572-86. [Content Brief]

[4]. Keijo M Viiri, et al. DNA-binding and -bending activities of SAP30L and SAP30 are mediated by a zinc-dependent module and monophosphoinositides. Mol Cell Biol. 2009 Jan;29(2):342-56. [Content Brief]

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