Major intrinsically disordered Notch2-binding receptor 1
Definition:
Intrinsically disordered protein which may negatively regulate mTOR signaling pathway by stabilizing the mTOR complex component DEPTOR. Negatively regulates angiogenesis. Negatively regulates cell growth. Negatively regulates neurite outgrowth in hippocampal neurons (By similarity).
Referencias:
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[1]. Hefei Zhang, et al. UBTOR/KIAA1024 regulates neurite outgrowth and neoplasia through mTOR signaling. PLoS Genet. 2018 Aug 6;14(8):e1007583. [Content Brief]
[2]. Rachel Xi-Yeen Ho, et al. MINAR1 is a Notch2-binding protein that inhibits angiogenesis and breast cancer growth. J Mol Cell Biol. 2018 Jun 1;10(3):195-204. [Content Brief]
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