Malate dehydrogenase, cytoplasmic

Definition:

Catalyzes the reduction of aromatic alpha-keto acids in the presence of NADH. Plays essential roles in the malate-aspartate shuttle and the tricarboxylic acid cycle, important in mitochondrial NADH supply for oxidative phosphorylation.

References:

[1]. C A Friedrich, et al. The reduction of aromatic alpha-keto acids by cytoplasmic malate dehydrogenase and lactate dehydrogenase. Biochem Genet. 1987 Oct;25(9-10):657-69. [Content Brief]

[2]. C A Friedrich, et al. Biochemical and genetic identity of alpha-keto acid reductase and cytoplasmic malate dehydrogenase from human erythrocytes. Ann Hum Genet. 1988 Jan;52(1):25-37. [Content Brief]

[3]. Melissa H Broeks, et al. MDH1 deficiency is a metabolic disorder of the malate-aspartate shuttle associated with early onset severe encephalopathy. Hum Genet. 2019 Dec;138(11-12):1247-1257. [Content Brief]

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