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  2. Maximum tolerated dose (MTD)

Maximum tolerated dose (MTD)

Definition:

Maximum tolerated dose (MTD) refers to the maximum dose that a chemical tolerated does not cause death of the tested subjects (experimental animals) in the acute toxicity test of foreign compounds. Beyond which a specific toxicity or action can not be attributed to a test substance due to the compromised state of the organism. MTD is often used as a basis for the selection of dose ranges in acute toxicity tests.

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