Mitochondria-associated ER membrane (MAM)

Definition:

Mitochondria-associated ER membrane (MAM) is a functional subdomain of the endoplasmic reticulum membrane that tethers to the mitochondrial outer membrane and is essential for cellular homeostasis. MAM disruption is a common pathological feature in amyotrophic lateral sclerosis.

References:

[1]. Sakai S, et al. Novel reporters of mitochondria-associated membranes (MAM), MAMtrackers, demonstrate MAM disruption as a common pathological feature in amyotrophic lateral sclerosis. FASEB J. 2021 Jul;35(7):e21688. [Content Brief]

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