Mitochondrial fission process protein 1
Definition:
Involved in the mitochondrial division probably by regulating membrane fission. Loss-of-function induces the release of cytochrome c, which activates the caspase cascade and leads to apoptosis.
References:
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[1]. Daniel Tondera, et al. The mitochondrial protein MTP18 contributes to mitochondrial fission in mammalian cells. J Cell Sci. 2005 Jul 15;118(Pt 14):3049-59. [Content Brief]
[2]. Daniel Tondera, et al. Knockdown of MTP18, a novel phosphatidylinositol 3-kinase-dependent protein, affects mitochondrial morphology and induces apoptosis. J Biol Chem. 2004 Jul 23;279(30):31544-55. [Content Brief]
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