Mitochondrial import receptor subunit TOM70

Definition:

Acts as receptor of the preprotein translocase complex of the outer mitochondrial membrane (TOM complex). Recognizes and mediates the translocation of mitochondrial preproteins from the cytosol into the mitochondria in a chaperone dependent manner. Mediates TBK1 and IRF3 activation induced by MAVS in response to Sendai virus infection and promotes host antiviral responses during virus infection. Upon Sendai virus infection, recruits HSP90AA1:IRF3:BAX in mitochondrion and the complex induces apoptosis.

References:

[1]. Bo Wei, et al. Tom70 mediates Sendai virus-induced apoptosis on mitochondria. J Virol. 2015 Apr;89(7):3804-18. [Content Brief]

[2]. Xin-Yi Liu, et al. Tom70 mediates activation of interferon regulatory factor 3 on mitochondria. Cell Res. 2010 Sep;20(9):994-1011. [Content Brief]

[3]. Xianhe Li, et al. Mitochondria shed their outer membrane in response to infection-induced stress. Science. 2022 Jan 14;375(6577):eabi4343. [Content Brief]

[4]. He-Wei Jiang, et al. SARS-CoV-2 Orf9b suppresses type I interferon responses by targeting TOM70. Cell Mol Immunol. 2020 Sep;17(9):998-1000. [Content Brief]

[5]. Jason C Young, et al. Molecular chaperones Hsp90 and Hsp70 deliver preproteins to the mitochondrial import receptor Tom70. Cell. 2003 Jan 10;112(1):41-50. [Content Brief]

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