N-lysine methyltransferase SETD6

Definition:

Protein-lysine N-methyltransferase. Monomethylates 'Lys-310' of the RELA subunit of NF-kappa-B complex, leading to down-regulation of NF-kappa-B transcription factor activity. Monomethylates 'Lys-8' of H2AZ (H2AZK8me1). Required for the maintenance of embryonic stem cell self-renewal (By similarity). Methylates PAK4.

References:

[1]. Lital Estrella Weil, et al. Oligomerization and Auto-methylation of the Human Lysine Methyltransferase SETD6. J Mol Biol. 2018 Oct 19;430(21):4359-4368. [Content Brief]

[2]. Yanqi Chang, et al. Structural basis of SETD6-mediated regulation of the NF-kB network via methyl-lysine signaling. Nucleic Acids Res. 2011 Aug;39(15):6380-9. [Content Brief]

[3]. Olivier Binda, et al. SETD6 monomethylates H2AZ on lysine 7 and is required for the maintenance of embryonic stem cell self-renewal. Epigenetics. 2013 Feb;8(2):177-83. [Content Brief]

[4]. Dan Levy, et al. Lysine methylation of the NF-κB subunit RelA by SETD6 couples activity of the histone methyltransferase GLP at chromatin to tonic repression of NF-κB signaling. Nat Immunol. 2011 Jan;12(1):29-36. [Content Brief]

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