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Protein DEPP1

Definition:

Acts as a critical modulator of FOXO3-induced autophagy via increased cellular ROS.

References:

[1]. S Salcher, et al. C10ORF10/DEPP-mediated ROS accumulation is a critical modulator of FOXO3-induced autophagy. Mol Cancer. 2017 May 25;16(1):95. [Content Brief]

[2]. Marcus W Stepp, et al. The c10orf10 gene product is a new link between oxidative stress and autophagy. Biochim Biophys Acta. 2014 Jun;1843(6):1076-88. [Content Brief]

[3]. Stefan Salcher, et al. C10ORF10/DEPP, a transcriptional target of FOXO3, regulates ROS-sensitivity in human neuroblastoma. Mol Cancer. 2014 Sep 28;13:224. [Content Brief]

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