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Protein FAM83D

Definition:

Through the degradation of FBXW7, may act indirectly on the expression and downstream signaling of MTOR, JUN and MYC. May play also a role in cell proliferation through activation of the ERK1/ERK2 signaling cascade. May also be important for proper chromosome congression and alignment during mitosis through its interaction with KIF22.

References:

[1]. Zeran Wang, et al. FAM83D promotes cell proliferation and motility by downregulating tumor suppressor gene FBXW7. Oncotarget. 2013 Dec;4(12):2476-86. [Content Brief]

[2]. Anna Santamaria, et al. The spindle protein CHICA mediates localization of the chromokinesin Kid to the mitotic spindle. Curr Biol. 2008 May 20;18(10):723-729. [Content Brief]

[3]. Dong Wang, et al. FAM83D activates the MEK/ERK signaling pathway and promotes cell proliferation in hepatocellular carcinoma. Biochem Biophys Res Commun. 2015 Mar 6;458(2):313-20. [Content Brief]

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