Ras-responsive element-binding protein 1

Definition:

Transcription factor that binds specifically to the RAS-responsive elements (RRE) of gene promoters. Represses the angiotensinogen gene. Negatively regulates the transcriptional activity of AR. Potentiates the transcriptional activity of NEUROD1. Promotes brown adipocyte differentiation (By similarity). May be involved in Ras/Raf-mediated cell differentiation by enhancing calcitonin expression.

References:

[1]. Nishit K Mukhopadhyay, et al. The zinc finger protein ras-responsive element binding protein-1 is a coregulator of the androgen receptor: implications for the role of the Ras pathway in enhancing androgenic signaling in prostate cancer. Mol Endocrinol. 2007 Sep;21(9):2056-70. [Content Brief]

[2]. L Zhang, et al. A human Raf-responsive zinc-finger protein that binds to divergent sequences. Nucleic Acids Res. 1999 Jul 15;27(14):2947-56. [Content Brief]

[3]. Shoichi Date, et al. Finb, a multiple zinc finger protein, represses transcription of the human angiotensinogen gene. Int J Mol Med. 2004 May;13(5):637-42. [Content Brief]

[4]. A Fujimoto-Nishiyama, et al. A novel zinc finger protein, Finb, is a transcriptional activator and localized in nuclear bodies. Gene. 1997 Aug 22;195(2):267-75. [Content Brief]

[5]. Subir K Ray, et al. Novel transcriptional potentiation of BETA2/NeuroD on the secretin gene promoter by the DNA-binding protein Finb/RREB-1. Mol Cell Biol. 2003 Jan;23(1):259-71. [Content Brief]

[6]. A Thiagalingam, et al. RREB-1, a novel zinc finger protein, is involved in the differentiation response to Ras in human medullary thyroid carcinomas. Mol Cell Biol. 1996 Oct;16(10):5335-45. [Content Brief]

Biomedical Dictionary

The Biomedical Dictionary is a comprehensive and professional collection of biological academic terms and subject datas. All explanations are supported by authoritative books or high impact factor literatures, and you can acquire accurate explanations of the biomedical terms you want to know.

A B C D E F G H I J K L M N O P Q R S T U V W X Y Z #

Name
Email *

	Sorry, but the email address you supplied was invalid.